Pagis-de Micco C, Tripier M F, Hassoun J, Meyer G, Toga M
C R Acad Hebd Seances Acad Sci D. 1976 Feb 16;282(7):683-5.
The authors report premilinary results of an experiment on permeability of the blood-brain barrier (BBB) to anti-tumor virus-induced immunological factors in the polyoma virus/Syrian Hamster system. The animals were protected by subcutaneous or intracranial injections with virus before challenge with polyoma virus transformed cells by both routes. BBB seemed to be permeable to the efferent part of the subcutaneously induced immune reaction. On the contrary, antigenic information introduced in the central nervous system was trapped inside the BBB. Thus the BBB might offer a "one-way" permeability in this system.
作者报告了在多瘤病毒/叙利亚仓鼠系统中，关于血脑屏障（BBB）对抗肿瘤病毒诱导的免疫因子通透性实验的初步结果。在用多瘤病毒转化细胞通过两种途径进行攻击之前，通过皮下或颅内注射病毒对动物进行保护。血脑屏障似乎对皮下诱导的免疫反应的传出部分具有通透性。相反，引入中枢神经系统的抗原信息被困在血脑屏障内。因此，在这个系统中血脑屏障可能具有“单向”通透性。
