Takács M, Ekiz-Gücer N, Reisch J, Gergely-Zobin A
Institut für Pharmazeutische Chemie, Semmelweis Medizinischen Universität.
Pharm Acta Helv. 1991;66(5-6):137-40.
The light sensitivity of corticosteroids in the solid state have been investigated and the photodecomposition rates of the compounds have been estimated by HPLC. After 48 h UV-irradiation desoxycortone acetate, hydrocortisone, hydrocortisone acetate, prednisolone, methylprednisolone, dexamethasone, betamethasone and triamcinolone acetonide decompose between 20 and 50%. Cortisone acetate, prednisone and fluocinolone acetonide show photostability in contrast to requirements of the Pharmacopeia for light protections.
