Kane M P, Tsuji K
J Pharm Sci. 1983 Jan;72(1):30-5. doi: 10.1002/jps.2600720108.
The cobalt 60 radiolytic degradation products have been identified in the following corticosteroids: cortisone, cortisone acetate, hydrocortisone, hydrocortisone acetate, hydrocortisone sodium succinate, isoflupredone acetate, methylprednisolone, methylprednisolone acetate, prednisolone, prednisolone acetate, and prednisone. Two major types of degradation processes have been identified: loss of the corticoid side chain on the D-ring to produce the C-17 ketone and conversion of the C-11 alcohol, if present, to the C-11 ketone. Minor degradation products derived from other changes affecting the side chain are also identified in several corticosteroids. These compounds are frequently associated in corticosteroids as process impurities or degradation compounds. No new radiolytic compounds unique to 60Co-irradiation have been found. The majority of corticosteroids have been shown to be stable to 60Co-irradiation. The rates of radiolytic degradation ranged from 0.2 to 1.4%/Mrad.
已在以下皮质类固醇中鉴定出钴60辐射降解产物：可的松、醋酸可的松、氢化可的松、醋酸氢化可的松、氢化可的松琥珀酸钠、醋酸异氟泼尼龙、甲泼尼龙、醋酸甲泼尼龙、泼尼松龙、醋酸泼尼松龙和泼尼松。已鉴定出两种主要的降解过程：D环上皮质类固醇侧链的丢失以产生C-17酮，以及将存在的C-11醇转化为C-11酮。在几种皮质类固醇中还鉴定出了源自影响侧链的其他变化的次要降解产物。这些化合物在皮质类固醇中经常作为工艺杂质或降解化合物存在。未发现60Co辐照特有的新的辐射分解化合物。大多数皮质类固醇已被证明对60Co辐照稳定。辐射降解率范围为0.2%至1.4%/兆拉德。
