Co-localization and interaction of DPYSL3 and GAP43 in primary cortical neurons.
作者信息
Kowara Renata, Ménard Michel, Brown Leslie, Chakravarthy Balu
机构信息
National Research Council, Institute for Biological Sciences, M-54, 1200 Montreal Road, Ottawa, Ont., Canada K1A 0R6.
出版信息
Biochem Biophys Res Commun. 2007 Nov 9;363(1):190-3. doi: 10.1016/j.bbrc.2007.08.163. Epub 2007 Sep 4.
PMID:17845802
Abstract
Dihydropyrimidinase-like 3 (DPYSL3) and GAP43 are both involved in neurite outgrowth, a crucial process for the differentiation of neurons. The present study shows for the first time that DPYSL3 co-localizes with GAP43 in primary cortical neurons. Further co-immunoprecipitation and overlay assay showed the ability of both recombinant and endogenous DPYSL3 to bind GAP43, indicating a specific interaction between DPYSL3 and GAP43 in primary cortical neurons.
摘要
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