Co-localization and interaction of DPYSL3 and GAP43 in primary cortical neurons.

Suppr

超能文献

作者信息

Kowara Renata, Ménard Michel, Brown Leslie, Chakravarthy Balu

机构信息

National Research Council, Institute for Biological Sciences, M-54, 1200 Montreal Road, Ottawa, Ont., Canada K1A 0R6.

出版信息

Biochem Biophys Res Commun. 2007 Nov 9;363(1):190-3. doi: 10.1016/j.bbrc.2007.08.163. Epub 2007 Sep 4.

DOI:10.1016/j.bbrc.2007.08.163

PMID:17845802

Abstract

Dihydropyrimidinase-like 3 (DPYSL3) and GAP43 are both involved in neurite outgrowth, a crucial process for the differentiation of neurons. The present study shows for the first time that DPYSL3 co-localizes with GAP43 in primary cortical neurons. Further co-immunoprecipitation and overlay assay showed the ability of both recombinant and endogenous DPYSL3 to bind GAP43, indicating a specific interaction between DPYSL3 and GAP43 in primary cortical neurons.

摘要

相似文献

Co-localization and interaction of DPYSL3 and GAP43 in primary cortical neurons.

Biochem Biophys Res Commun. 2007 Nov 9;363(1):190-3. doi: 10.1016/j.bbrc.2007.08.163. Epub 2007 Sep 4.

Involvement of nitric oxide synthase and ROS-mediated activation of L-type voltage-gated Ca2+ channels in NMDA-induced DPYSL3 degradation.

Brain Res. 2006 Nov 13;1119(1):40-9. doi: 10.1016/j.brainres.2006.08.047. Epub 2006 Sep 20.

Calpain-mediated truncation of dihydropyrimidinase-like 3 protein (DPYSL3) in response to NMDA and H2O2 toxicity.

J Neurochem. 2005 Oct;95(2):466-74. doi: 10.1111/j.1471-4159.2005.03383.x. Epub 2005 Aug 31.

PLA(2) signaling is involved in calpain-mediated degradation of synaptic dihydropyrimidinase-like 3 protein in response to NMDA excitotoxicity.

Neurosci Lett. 2008 Jan 17;430(3):197-202. doi: 10.1016/j.neulet.2007.10.036. Epub 2007 Nov 5.

Axonal localization of neuritin/CPG15 mRNA is limited by competition for HuD binding.

J Cell Sci. 2017 Nov 1;130(21):3650-3662. doi: 10.1242/jcs.201244. Epub 2017 Sep 4.

Dl-3-n-butylphthalide promotes neurite outgrowth of primary cortical neurons by Sonic Hedgehog signaling via upregulating Gap43.

Exp Cell Res. 2021 Jan 15;398(2):112420. doi: 10.1016/j.yexcr.2020.112420. Epub 2020 Dec 6.

Glial-derived S100b protein selectively inhibits recombinant beta protein kinase C (PKC) phosphorylation of neuron-specific protein F1/GAP43.

Brain Res Mol Brain Res. 1994 Jan;21(1-2):62-6. doi: 10.1016/0169-328x(94)90378-6.

Shared and unique roles of CAP23 and GAP43 in actin regulation, neurite outgrowth, and anatomical plasticity.

J Cell Biol. 2000 Jun 26;149(7):1443-54. doi: 10.1083/jcb.149.7.1443.

GAP43 overexpression and enhanced neurite outgrowth in mucopolysaccharidosis type IIIB cortical neuron cultures.

J Neurosci Res. 2010 Jan;88(1):202-13. doi: 10.1002/jnr.22190.

Association of Gap-43 (neuromodulin) with microtubule-associated protein MAP-2 in neuronal cells.

Biochem Biophys Res Commun. 2008 Jul 11;371(4):679-83. doi: 10.1016/j.bbrc.2008.04.119. Epub 2008 May 1.

引用本文的文献

Repurposing the hypoglycaemic agents for neuroinflammation, a comprehensive review.

3 Biotech. 2025 Sep;15(9):281. doi: 10.1007/s13205-025-04455-7. Epub 2025 Aug 5.

A transcriptomic and proteomic analysis and comparison of human brain tissue from patients with and without epilepsy.

Sci Rep. 2025 May 11;15(1):16369. doi: 10.1038/s41598-025-00986-4.

Length biases in single-cell RNA sequencing of pre-mRNA.

Biophys Rep (N Y). 2022 Dec 27;3(1):100097. doi: 10.1016/j.bpr.2022.100097. eCollection 2023 Mar 8.

A Unique Family of Neuronal Signaling Proteins Implicated in Oncogenesis and Tumor Suppression.

Front Oncol. 2019 Apr 17;9:289. doi: 10.3389/fonc.2019.00289. eCollection 2019.

Human CRMP4 mutation and disrupted Crmp4 expression in mice are associated with ASD characteristics and sexual dimorphism.

Sci Rep. 2017 Dec 1;7(1):16812. doi: 10.1038/s41598-017-16782-8.

Deletion of collapsin response mediator protein 4 results in abnormal layer thickness and elongation of mitral cell apical dendrites in the neonatal olfactory bulb.

J Anat. 2016 May;228(5):792-804. doi: 10.1111/joa.12434. Epub 2016 Jan 6.

Gene expression analyses of the spatio-temporal relationships of human medulloblastoma subgroups during early human neurogenesis.

PLoS One. 2014 Nov 20;9(11):e112909. doi: 10.1371/journal.pone.0112909. eCollection 2014.

Postnatal alteration of collapsin response mediator protein 4 mRNA expression in the mouse brain.

J Anat. 2012 Oct;221(4):341-51. doi: 10.1111/j.1469-7580.2012.01544.x. Epub 2012 Jul 22.

Identification of novel ryanodine receptor 1 (RyR1) protein interaction with calcium homeostasis endoplasmic reticulum protein (CHERP).

J Biol Chem. 2011 May 13;286(19):17060-8. doi: 10.1074/jbc.M110.197186. Epub 2011 Mar 14.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验