胶质瘤密码：调控细胞命运、干性和癌症的信息枢纽。
The Gli code: an information nexus regulating cell fate, stemness and cancer.
作者信息
Ruiz i Altaba Ariel, Mas Christophe, Stecca Barbara
机构信息
Department of Genetic Medicine and Development, 8242 CMU, University of Geneva Medical School, 1 rue Michel Servet, CH-1211 Geneva, Switzerland.
出版信息
Trends Cell Biol. 2007 Sep;17(9):438-47. doi: 10.1016/j.tcb.2007.06.007. Epub 2007 Sep 12.
Abstract
The Gli code hypothesis postulates that the three vertebrate Gli transcription factors act together in responding cells to integrate intercellular Hedgehog (Hh) and other signaling inputs, resulting in the regulation of tissue pattern, size and shape. Hh and other inputs are then just ways to modify the Gli code. Recent data confirm this idea and suggest that the Gli code regulates stemness and also tumor progression and metastatic growth, opening exciting possibilities for both regenerative medicine and novel anticancer therapies.
摘要
Gli编码假说假定，三种脊椎动物Gli转录因子在响应细胞中共同作用，整合细胞间的刺猬信号通路（Hh）和其他信号输入，从而调节组织的模式、大小和形状。Hh和其他输入只是修改Gli编码的方式。最近的数据证实了这一观点，并表明Gli编码调节干性以及肿瘤进展和转移生长，为再生医学和新型抗癌疗法开辟了令人兴奋的可能性。
相似文献
1
The Gli code: an information nexus regulating cell fate, stemness and cancer.胶质瘤密码：调控细胞命运、干性和癌症的信息枢纽。
Trends Cell Biol. 2007 Sep;17(9):438-47. doi: 10.1016/j.tcb.2007.06.007. Epub 2007 Sep 12.
2
Yeast-based assay identifies novel Shh/Gli target genes in vertebrate development.酵母测定法鉴定脊椎动物发育中新型 Shh/Gli 靶基因。
BMC Genomics. 2012 Jan 3;13:2. doi: 10.1186/1471-2164-13-2.
3
All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3.刺猬因子介导的所有小鼠腹侧脊髓模式形成都依赖Gli，且涉及Gli3的激活功能。
Dev Cell. 2004 Jan;6(1):103-15. doi: 10.1016/s1534-5807(03)00394-0.
4
Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator.由酪蛋白激酶1介导的刺猬因子诱导的磷酸化作用维持Ci/Gli激活因子的活性。
Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):E5651-60. doi: 10.1073/pnas.1416652111. Epub 2014 Dec 15.
5
Hedgehog and Gli signaling in embryonic mammary gland development.刺猬和 Gli 信号在胚胎乳腺发育中的作用。
J Mammary Gland Biol Neoplasia. 2013 Jun;18(2):133-8. doi: 10.1007/s10911-013-9291-7. Epub 2013 May 16.
6
Hedgehogs: la dolce vita. Workshop on Hedgehog-Gli Signaling in Cancer and Stem Cells.刺猬：甜蜜生活。癌症与干细胞中的刺猬-胶质瘤信号传导研讨会。
EMBO Rep. 2007 May;8(5):451-5. doi: 10.1038/sj.embor.7400959. Epub 2007 Apr 13.
7
HEDGEHOG/GLI-E2F1 axis modulates iASPP expression and function and regulates melanoma cell growth.刺猬索尼克信号通路/胶质瘤相关癌基因同源物E2F1轴调节iASPP的表达和功能，并调控黑色素瘤细胞的生长。
Cell Death Differ. 2015 Dec;22(12):2006-19. doi: 10.1038/cdd.2015.56. Epub 2015 May 29.
8
A dynamic Gli code interprets Hh signals to regulate induction, patterning, and endocrine cell specification in the zebrafish pituitary.一种动态的Gli编码解读Hh信号，以调节斑马鱼垂体中的诱导、模式形成和内分泌细胞特化。
Dev Biol. 2009 Feb 1;326(1):143-54. doi: 10.1016/j.ydbio.2008.11.006. Epub 2008 Nov 20.
9
Sonic Hedgehog-GLI Family Zinc Finger 1 Signaling Pathway Promotes the Growth and Migration of Pancreatic Cancer Cells by Regulating the Transcription of Eukaryotic Translation Initiation Factor 5A2.音猬因子-GLI家族锌指蛋白1信号通路通过调控真核翻译起始因子5A2的转录促进胰腺癌细胞的生长和迁移。
Pancreas. 2015 Nov;44(8):1252-8. doi: 10.1097/MPA.0000000000000532.
10
The Sonic hedgehog pathway independently controls the patterning, proliferation and survival of neuroepithelial cells by regulating Gli activity.音猬因子信号通路通过调节Gli活性，独立控制神经上皮细胞的模式形成、增殖和存活。
Development. 2006 Feb;133(3):517-28. doi: 10.1242/dev.02228.
引用本文的文献
1
Hedgehog Signalling in Osteogenesis and Bone Metabolism: Molecular Mechanisms, Regulatory Networks and Implications for Skeletal Disease.刺猬信号通路在骨生成和骨代谢中的作用：分子机制、调控网络及其对骨骼疾病的影响
J Cell Mol Med. 2025 Aug;29(16):e70813. doi: 10.1111/jcmm.70813.
2
Triterpenoid derivatives inhibit Gli-mediated transcription in human glioblastoma cell line via direct interaction with Gli1.三萜类衍生物通过与Gli1直接相互作用抑制人胶质母细胞瘤细胞系中Gli介导的转录。
J Biol Chem. 2025 Jul 10;301(9):110472. doi: 10.1016/j.jbc.2025.110472.
3
Eugenol Promotes Apoptosis in Leukemia Cells via Targeting the Mitochondrial Biogenesis PPRC1 Gene.丁香酚通过靶向线粒体生物发生相关基因PPRC1促进白血病细胞凋亡。
Cells. 2025 Feb 12;14(4):260. doi: 10.3390/cells14040260.
4
Applying Spinal Cord Organoids as a quantitative approach to study the mammalian Hedgehog pathway.应用脊髓类器官作为一种定量方法来研究哺乳动物 Hedgehog 通路。
PLoS One. 2024 Jun 25;19(6):e0301670. doi: 10.1371/journal.pone.0301670. eCollection 2024.
5
Transcription factor EHF drives cholangiocarcinoma development through transcriptional activation of glioma-associated oncogene homolog 1 and chemokine CCL2.转录因子EHF通过激活胶质瘤相关癌基因同源物1和趋化因子CCL2的转录来驱动胆管癌的发展。
MedComm (2020). 2024 May 13;5(5):e535. doi: 10.1002/mco2.535. eCollection 2024 May.
6
Role of Hedgehog Signaling Pathways in Multipotent Mesenchymal Stem Cells Differentiation.Hedgehog 信号通路在多能间充质干细胞分化中的作用。
Cell Transplant. 2024 Jan-Dec;33:9636897241244943. doi: 10.1177/09636897241244943.
7
Neurogenic Effects of Inorganic Arsenic and Cdk5 Knockdown in Zebrafish Embryos: A Perspective on Modeling Autism.无机砷和 Cdk5 敲低在斑马鱼胚胎中的神经毒性作用：自闭症模型的一个视角。
Int J Mol Sci. 2024 Mar 19;25(6):3459. doi: 10.3390/ijms25063459.
8
The comprehensive landscape of prognosis, immunity, and function of the GLI family by pan-cancer and single-cell analysis.通过泛癌症和单细胞分析全面描绘 GLI 家族的预后、免疫和功能景观。
Aging (Albany NY). 2024 Mar 18;16(6):5123-5148. doi: 10.18632/aging.205630.
9
KIT mutations and expression: current knowledge and new insights for overcoming IM resistance in GIST.KIT 突变和表达：克服 GIST 中 IM 耐药的最新知识和新见解。
Cell Commun Signal. 2024 Feb 27;22(1):153. doi: 10.1186/s12964-023-01411-x.
10
Cycloastragenol inhibits adipogenesis and fat accumulation in vitro and in vivo through activating Hedgehog signaling.环黄芪醇通过激活刺猬信号通路在体外和体内抑制脂肪生成和脂肪积累。
Food Sci Biotechnol. 2023 Sep 16;33(3):711-720. doi: 10.1007/s10068-023-01403-0. eCollection 2024 Feb.
本文引用的文献
1
Patched1 regulates hedgehog signaling at the primary cilium.Patched1在初级纤毛处调节刺猬信号通路。
Science. 2007 Jul 20;317(5836):372-6. doi: 10.1126/science.1139740.
2
Essential role of stromally induced hedgehog signaling in B-cell malignancies.基质诱导的刺猬信号通路在B细胞恶性肿瘤中的关键作用。
Nat Med. 2007 Aug;13(8):944-51. doi: 10.1038/nm1614. Epub 2007 Jul 15.
3
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists.小分子拮抗剂对GLI介导的转录和肿瘤细胞生长的抑制作用。
Proc Natl Acad Sci U S A. 2007 May 15;104(20):8455-60. doi: 10.1073/pnas.0609699104. Epub 2007 May 9.
4
Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning.音猬因子介导的神经模式形成中Gli激活因子靶点的基因组特征分析。
Development. 2007 May;134(10):1977-89. doi: 10.1242/dev.001966. Epub 2007 Apr 18.
5
Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.黑色素瘤需要由GLI1与RAS-MEK/AKT通路之间的相互作用所调控的HEDGEHOG-GLI信号传导。
Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5895-900. doi: 10.1073/pnas.0700776104. Epub 2007 Mar 28.
6
Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma.刺猬信号通路维持多发性骨髓瘤中的肿瘤干细胞区室。
Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4048-53. doi: 10.1073/pnas.0611682104. Epub 2007 Feb 27.
7
Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells.致癌性KRAS激活胰腺癌细胞中的刺猬信号通路。
J Biol Chem. 2007 May 11;282(19):14048-55. doi: 10.1074/jbc.M611089200. Epub 2007 Mar 12.
8
Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers.抑制刺猬信号通路可抑制胰腺癌的侵袭和转移：实体癌联合治疗的新范例。
Cancer Res. 2007 Mar 1;67(5):2187-96. doi: 10.1158/0008-5472.CAN-06-3281.
9
Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling.抑制性Gli3活性对Wnt/β-连环蛋白信号通路起负向调节作用。
Curr Biol. 2007 Mar 20;17(6):545-50. doi: 10.1016/j.cub.2007.01.062. Epub 2007 Mar 1.
10
Multiple ubiquitin-dependent processing pathways regulate hedgehog/gli signaling: implications for cell development and tumorigenesis.多种泛素依赖性加工途径调控刺猬因子/胶质瘤相关癌基因信号通路：对细胞发育和肿瘤发生的影响
Cell Cycle. 2007 Feb 15;6(4):390-3. doi: 10.4161/cc.6.4.3809. Epub 2007 Feb 3.
Zotero 插件