Ruiz i Altaba Ariel, Mas Christophe, Stecca Barbara
Department of Genetic Medicine and Development, 8242 CMU, University of Geneva Medical School, 1 rue Michel Servet, CH-1211 Geneva, Switzerland.
Trends Cell Biol. 2007 Sep;17(9):438-47. doi: 10.1016/j.tcb.2007.06.007. Epub 2007 Sep 12.
The Gli code hypothesis postulates that the three vertebrate Gli transcription factors act together in responding cells to integrate intercellular Hedgehog (Hh) and other signaling inputs, resulting in the regulation of tissue pattern, size and shape. Hh and other inputs are then just ways to modify the Gli code. Recent data confirm this idea and suggest that the Gli code regulates stemness and also tumor progression and metastatic growth, opening exciting possibilities for both regenerative medicine and novel anticancer therapies.
Gli编码假说假定，三种脊椎动物Gli转录因子在响应细胞中共同作用，整合细胞间的刺猬信号通路（Hh）和其他信号输入，从而调节组织的模式、大小和形状。Hh和其他输入只是修改Gli编码的方式。最近的数据证实了这一观点，并表明Gli编码调节干性以及肿瘤进展和转移生长，为再生医学和新型抗癌疗法开辟了令人兴奋的可能性。
