Barragan-Rodríguez Lázaro, Rodríguez-Morán Martha, Guerrero-Romero Fernando
Medical Research Unit in Clinical Epidemiology, Mexican Social Security Institute (IMSS), Durango, Mexico.
Arch Med Res. 2007 Oct;38(7):752-6. doi: 10.1016/j.arcmed.2007.03.008. Epub 2007 May 16.
We undertook this study to assess the hypothesis that hypomagnesemia is associated with depressive symptoms in older people with diabetes.
A total of 55 type 2 diabetic patients, aged 65 years or older, with depressive symptoms were compared with a control group of diabetic subjects without depressive symptoms in an age- and gender-matched case/control study. A score >or=11 points in the Yesavage's scale was used for defining depressive symptoms, and hypomagnesemia was defined by serum magnesium levels <0.74 mmol/L. Well-known causes for depression as well as diseases and drugs that may cause depressive symptoms or hypomagnesemia were exclusion criteria.
Serum magnesium levels were significantly lower among depressive than control diabetic subjects (0.74 +/- 0.25 vs. 0.86 +/- 0.29 mmol/L, p = 0.02). Twenty four (43.6%) and 7 (12.7%) individuals in the case and control group exhibited low serum magnesium levels (p = 0.0006). The adjusted logistic regression analysis showed an independent association between hypomagnesemia and depressive symptoms (OR 1.79; CI(95%) 1.1-6.9, p = 0.03).
Our results suggest that hypomagnesemia is independently associated with depressive symptoms in older people with diabetes.
我们开展这项研究以评估低镁血症与老年糖尿病患者抑郁症状相关这一假说。
在一项年龄和性别匹配的病例对照研究中，将55名年龄在65岁及以上且有抑郁症状的2型糖尿病患者与一组无抑郁症状的糖尿病对照受试者进行比较。采用耶萨维奇量表评分≥11分来定义抑郁症状，血清镁水平<0.74 mmol/L定义为低镁血症。排除已知的抑郁症病因以及可能导致抑郁症状或低镁血症的疾病和药物作为纳入标准。
抑郁的糖尿病受试者血清镁水平显著低于对照受试者（0.74±0.25 vs. 0.86±0.29 mmol/L，p = 0.02）。病例组和对照组分别有24人（43.6%）和7人（12.7%）血清镁水平较低（p = 0.0006）。校正后的逻辑回归分析显示低镁血症与抑郁症状之间存在独立关联（比值比1.79；95%置信区间1.1 - 6.9，p = 0.03）。
我们的结果表明，低镁血症与老年糖尿病患者的抑郁症状独立相关。
