Guerrero-Romero Fernando, Rodríguez-Morán Martha
Medical Research Unit in Clinical Epidemiology, Mexican Social Security Institute, Research Group on Diabetes and Chronic Illnesses, Siqueiros 225 esq./Castañeda, 34000 Durango, Mexico.
Diabetes Metab Res Rev. 2006 Nov-Dec;22(6):471-6. doi: 10.1002/dmrr.644.
Although hypomagnesemia, oxidative stress, and inflammation are involved in the pathogenesis of cardiovascular diseases, there is not a previous description concerning their potential interaction; thus, the aim of this study was to examine the relationship between metabolic syndrome (MetS), hypomagnesemia, inflammation, and oxidative stress.
Case-control design study. Incident cases of MetS (84 women and 63 men) were compared with healthy control subjects (163 women and 131 men) matched by age and gender. MetS was diagnosed according to the Adult Treatment Panel III (ATP III) criterion. Oxidative stress was defined by serum malondialdehyde concentration (MDA) > or =50 mg/dL, low-grade chronic inflammation by C-reactive protein (CRP) serum levels > or =3 mg/L, and hypomagnesemia by serum magnesium concentrations < or =1.8 mg/dL.
Multivariate analysis adjusted by age, sex, body mass index, waist-to-hip ratio, and total adiposity showed a strong association between MetS and hypomagnesemia (OR 1.9; 95% CI 1.3-7.1), inflammation (OR 1.7; 95% CI 1.4-8.4), and oxidative stress (OR 1.4; 95% CI 0.9-12.6). Additional adjustment by CRP levels showed that MetS remained associated to hypomagnesemia (OR 1.4; 95% CI 1.1-5.9) but not to oxidative stress (OR 1.1; 95% CI 0.9-5.9), and adjusted by MDA levels, MetS remained strongly associated to hypomagnesemia (1.6; CI 95% 1.1-7.4), but not to inflammation (OR 1.05; 95% CI 0.97-14.2). Adjusted by serum magnesium levels, inflammation (OR 1.2; 95% CI 1.1-9.1) and oxidative stress (OR 1.1; 95% CI 1.1-9.7) were slightly associated to MetS.
The interaction of inflammation and oxidative stress is related and increases the risk for MetS, whereas serum magnesium levels and MetS are independently associated.
尽管低镁血症、氧化应激和炎症参与心血管疾病的发病机制，但此前尚无关于它们潜在相互作用的描述；因此，本研究旨在探讨代谢综合征（MetS）、低镁血症、炎症和氧化应激之间的关系。
病例对照设计研究。将MetS的新发病例（84名女性和63名男性）与按年龄和性别匹配的健康对照者（163名女性和131名男性）进行比较。根据成人治疗小组第三次报告（ATP III）标准诊断MetS。氧化应激定义为血清丙二醛浓度（MDA）≥50mg/dL，低度慢性炎症定义为血清C反应蛋白（CRP）水平≥3mg/L，低镁血症定义为血清镁浓度≤1.8mg/dL。
经年龄、性别、体重指数、腰臀比和总体脂调整的多变量分析显示，MetS与低镁血症（比值比1.9；95%置信区间1.3 - 7.1）、炎症（比值比1.7；95%置信区间1.4 - 8.4）和氧化应激（比值比1.4；95%置信区间0.9 - 12.6）之间存在强关联。经CRP水平进一步调整显示，MetS仍与低镁血症相关（比值比1.4；95%置信区间1.1 - 5.9），但与氧化应激无关（比值比1.1；95%置信区间0.9 - 5.9）；经MDA水平调整后，MetS仍与低镁血症密切相关（1.6；95%置信区间1.1 - 7.4），但与炎症无关（比值比1.05；95%置信区间0.97 - 14.2）。经血清镁水平调整后，炎症（比值比1.2；95%置信区间1.1 - 9.1）和氧化应激（比值比1.1；95%置信区间1.1 - 9.7）与MetS有轻微关联。
炎症和氧化应激相互作用且增加MetS风险，而血清镁水平与MetS独立相关。
