镁与情绪障碍：系统评价与荟萃分析
Magnesium and mood disorders: systematic review and meta-analysis.
作者信息
Phelan Danny, Molero Patricio, Martínez-González Miguel A, Molendijk Marc
机构信息
Institute of Psychology,Clinical Psychology Unit,Leiden University,Leiden,The Netherlands.
Department of Psychiatry and Medical Psychology,University Hospital,School of Medicine,University of Navarra,Pamplona,Navarra,Spain.
出版信息
BJPsych Open. 2018 Jul;4(4):167-179. doi: 10.1192/bjo.2018.22.
BACKGROUND
Magnesium (Mg2+) has received considerable attention with regards to its potential role in the pathophysiology of the mood disorders, but the available evidence seems inconclusive.AimsTo review and quantitatively summarise the human literature on Mg2+ intake and Mg2+ blood levels in the mood disorders and the effects of Mg2+ supplements on mood.
METHOD
Systematic review and meta-analyses.
RESULTS
Adherence to a Mg2+-rich diet was negatively associated with depression in cross-sectional (odds ratio = 0.66) but not in prospective studies. Mg2+ levels in bodily fluids were on average higher in patients with a mood disorder (Hedge's g = 0.19), but only in patients treated with antidepressants and/or mood stabilisers. There was no evident association between Mg2+ levels and symptom severity. Mg2+ supplementation was associated with a decline in depressive symptoms in uncontrolled (g = -1.60) but not in placebo-controlled trials (g = -0.21).
CONCLUSION
Our results provide little evidence for the involvement of Mg2+ in the mood disorders.Declaration of interestNone.
背景
镁离子（Mg2+）在情绪障碍的病理生理学中的潜在作用已受到广泛关注，但现有证据似乎尚无定论。
目的
回顾并定量总结关于情绪障碍中镁离子摄入、血液中镁离子水平以及镁补充剂对情绪影响的人类文献。
方法
系统评价和荟萃分析。
结果
在横断面研究中，坚持富含镁的饮食与抑郁呈负相关（优势比 = 0.66），但在前瞻性研究中并非如此。情绪障碍患者体液中的镁离子水平平均较高（赫奇斯g值 = 0.19），但仅在接受抗抑郁药和/或情绪稳定剂治疗的患者中如此。镁离子水平与症状严重程度之间没有明显关联。在非对照试验中，补充镁与抑郁症状减轻有关（g值 = -1.60），但在安慰剂对照试验中并非如此（g值 = -0.21）。
结论
我们的结果几乎没有证据表明镁离子参与情绪障碍。
利益声明
无。
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