Robert Caroline
Service de dermatologie, Institut Gustave Roussy, 39, rue Camille-Desmoulins, 94800 Villejuif.
Bull Cancer. 2007 Jul;94 Spec No:S260-4.
Antiangiogenic agents can be associated with cutaneous side effects with a new and original spectrum of skin symptoms. A correlation between the molecular targets and skin manifestations is proposed. Further prospective studies are necessary in order to evaluate the potential association between skin side effects and clinical response. Systematic report and characterization of side effects occurring with new targeted therapies is critical. It will help us understanding better skin pathophysiology, but, most of all, it will lead to more efficient symptomatic treatment for our patients.
抗血管生成药物可能会伴有一系列新的、独特的皮肤症状等皮肤副作用。本文提出了分子靶点与皮肤表现之间的相关性。有必要开展进一步的前瞻性研究，以评估皮肤副作用与临床反应之间的潜在关联。对新靶向治疗中出现的副作用进行系统报告和特征描述至关重要。这将有助于我们更好地理解皮肤病理生理学，但最重要的是，它将为我们的患者带来更有效的对症治疗。
