Tan Zheng, Randall Glenn, Fan Jihua, Camoretti-Mercado Blanca, Brockman-Schneider Rebecca, Pan Lin, Solway Julian, Gern James E, Lemanske Robert F, Nicolae Dan, Ober Carole
Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
Am J Hum Genet. 2007 Oct;81(4):829-34. doi: 10.1086/521200. Epub 2007 Aug 20.
HLA-G is a nonclassic, class I HLA molecule that has important immunomodulatory properties. Previously, we identified HLA-G as an asthma-susceptibility gene and discovered that the risk of asthma in a child was determined by both the child's HLA-G genotype and the mother's affection status. Here we report a SNP in the 3' untranslated region of HLA-G that influences the targeting of three microRNAs (miRNAs) to this gene, and we suggest that allele-specific targeting of these miRNAs accounts, at least in part, for our earlier observations on HLA-G and the risk of asthma.
HLA-G是一种具有重要免疫调节特性的非经典I类HLA分子。此前，我们将HLA-G鉴定为哮喘易感基因，并发现儿童患哮喘的风险由儿童的HLA-G基因型和母亲的患病状况共同决定。在此我们报告HLA-G 3'非翻译区的一个单核苷酸多态性（SNP），该SNP影响三种微小RNA（miRNA）对该基因的靶向作用，并且我们认为这些miRNA的等位基因特异性靶向作用至少部分解释了我们之前关于HLA-G与哮喘风险的观察结果。
