微小RNA对HLA - G的等位基因特异性靶向作用与哮喘风险
Allele-specific targeting of microRNAs to HLA-G and risk of asthma.
作者信息
Tan Zheng, Randall Glenn, Fan Jihua, Camoretti-Mercado Blanca, Brockman-Schneider Rebecca, Pan Lin, Solway Julian, Gern James E, Lemanske Robert F, Nicolae Dan, Ober Carole
机构信息
Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
出版信息
Am J Hum Genet. 2007 Oct;81(4):829-34. doi: 10.1086/521200. Epub 2007 Aug 20.
Abstract
HLA-G is a nonclassic, class I HLA molecule that has important immunomodulatory properties. Previously, we identified HLA-G as an asthma-susceptibility gene and discovered that the risk of asthma in a child was determined by both the child's HLA-G genotype and the mother's affection status. Here we report a SNP in the 3' untranslated region of HLA-G that influences the targeting of three microRNAs (miRNAs) to this gene, and we suggest that allele-specific targeting of these miRNAs accounts, at least in part, for our earlier observations on HLA-G and the risk of asthma.
摘要
HLA-G是一种具有重要免疫调节特性的非经典I类HLA分子。此前，我们将HLA-G鉴定为哮喘易感基因，并发现儿童患哮喘的风险由儿童的HLA-G基因型和母亲的患病状况共同决定。在此我们报告HLA-G 3'非翻译区的一个单核苷酸多态性（SNP），该SNP影响三种微小RNA（miRNA）对该基因的靶向作用，并且我们认为这些miRNA的等位基因特异性靶向作用至少部分解释了我们之前关于HLA-G与哮喘风险的观察结果。
相似文献
1
Allele-specific targeting of microRNAs to HLA-G and risk of asthma.微小RNA对HLA - G的等位基因特异性靶向作用与哮喘风险
Am J Hum Genet. 2007 Oct;81(4):829-34. doi: 10.1086/521200. Epub 2007 Aug 20.
2
In silico analysis of microRNAS targeting the HLA-G 3' untranslated region alleles and haplotypes.针对 HLA-G 3'非翻译区等位基因和单倍型的 microRNA 的计算机分析。
Hum Immunol. 2009 Dec;70(12):1020-5. doi: 10.1016/j.humimm.2009.07.028. Epub 2009 Aug 5.
3
The 3'-untranslated region of the HLA-G gene in relation to pre-eclampsia: revisited.与子痫前期相关的HLA - G基因3'非翻译区：再探讨。
Tissue Antigens. 2010 Mar;75(3):253-61. doi: 10.1111/j.1399-0039.2009.01435.x. Epub 2010 Jan 12.
4
Association of the HLA-G gene +3142C>G polymorphism with systemic lupus erythematosus.HLA-G基因+3142C>G多态性与系统性红斑狼疮的关联
Tissue Antigens. 2011 Jun;77(6):540-5. doi: 10.1111/j.1399-0039.2011.01635.x. Epub 2011 Mar 14.
5
HLA-G: an asthma gene on chromosome 6p.
Immunol Allergy Clin North Am. 2005 Nov;25(4):669-79. doi: 10.1016/j.iac.2005.08.001.
6
Human leukocyte antigen-G polymorphism in relation to expression, function, and disease.人类白细胞抗原-G 多态性与表达、功能和疾病的关系。
Hum Immunol. 2009 Dec;70(12):1026-34. doi: 10.1016/j.humimm.2009.07.015. Epub 2009 Aug 6.
7
Population genetic studies of HLA-G: allele frequencies and linkage disequilibrium with HLA-A1.HLA-G的群体遗传学研究：等位基因频率及与HLA-A1的连锁不平衡
J Reprod Immunol. 1996 Dec;32(2):111-23. doi: 10.1016/s0165-0378(96)01000-5.
8
The genetic structure of 3'untranslated region of the HLA-G gene: polymorphisms and haplotypes.HLA-G 基因 3'非翻译区的遗传结构：多态性和单倍型。
Genes Immun. 2010 Mar;11(2):134-41. doi: 10.1038/gene.2009.74. Epub 2009 Oct 1.
9
Linkage disequilibrium between human leukocyte antigen (HLA) class II and HLA-G--possible implications for human reproduction and autoimmune disease.人类白细胞抗原（HLA）II类分子与HLA - G之间的连锁不平衡——对人类生殖和自身免疫性疾病的潜在影响
Hum Immunol. 2005 Jun;66(6):688-99. doi: 10.1016/j.humimm.2005.03.003.
10
Human leukocyte antigen-G 3' untranslated region polymorphisms are associated with asthma severity.人类白细胞抗原-G 3'非翻译区多态性与哮喘严重程度相关。
Mol Immunol. 2018 Sep;101:500-506. doi: 10.1016/j.molimm.2018.08.013. Epub 2018 Aug 22.
引用本文的文献
1
Mechanism of microRNA-152 Regulating Decidual Natural Killer Cell Viability and Affecting Trophoblast Cell Invasiveness via the HLA-G/KIR2DL4 Axis.微小RNA-152通过HLA-G/KIR2DL4轴调控蜕膜自然杀伤细胞活力并影响滋养层细胞侵袭的机制
Kaohsiung J Med Sci. 2025 May;41(5):e70019. doi: 10.1002/kjm2.70019. Epub 2025 May 1.
2
Human leukocyte antigen-G in hepatocellular carcinoma driven by chronic viral hepatitis or steatotic liver disease.慢性病毒性肝炎或脂肪性肝病所致肝细胞癌中的人类白细胞抗原-G
Sci Rep. 2025 Apr 17;15(1):13331. doi: 10.1038/s41598-025-97406-4.
3
Influence of HLA-G 3' Untranslated Region Haplotypes and SNP +3422 Gene Variants as Host Genetic Factors on the Outcomes of SARS-CoV-2 Infection During Acute and Post-Acute Phases in a German Cohort.HLA-G 3'非翻译区单倍型和SNP +3422基因变异作为宿主遗传因素对德国队列中急性和急性后期SARS-CoV-2感染结局的影响
HLA. 2024 Dec;104(6):e15799. doi: 10.1111/tan.15799.
4
HLA-G high-expressor 3'UTR markers are linked to gastric cancer development and survival.HLA-G 高表达 3'UTR 标志物与胃癌的发生和生存相关。
Cancer Immunol Immunother. 2024 Nov 16;74(1):26. doi: 10.1007/s00262-024-03771-w.
5
Variation within the non-coding genome influences genetic and epigenetic regulation of the human leukocyte antigen genes.非编码基因组内的变异影响人类白细胞抗原基因的遗传和表观遗传调控。
Front Immunol. 2024 Sep 17;15:1422834. doi: 10.3389/fimmu.2024.1422834. eCollection 2024.
6
Association of HLA-G 3'UTR polymorphisms with hepatitis B virus infection in Tunisian population.HLA-G 3'UTR 多态性与突尼斯人群乙型肝炎病毒感染的关联。
Immunol Res. 2024 Oct;72(5):1136-1146. doi: 10.1007/s12026-024-09516-2. Epub 2024 Jul 6.
7
Pinpointing Functionally Relevant miRNAs in Classical Hodgkin Lymphoma Pathogenesis.确定经典型霍奇金淋巴瘤发病机制中功能相关的微小RNA
Cancers (Basel). 2024 Mar 12;16(6):1126. doi: 10.3390/cancers16061126.
8
Changes in miRNA expression in the lungs of pigs supplemented with different levels and forms of vitamin D.补充不同水平和形式的维生素 D 对猪肺部 miRNA 表达的影响。
Mol Biol Rep. 2023 Dec 12;51(1):8. doi: 10.1007/s11033-023-08940-1.
9
Leveraging molecular quantitative trait loci to comprehend complex diseases/traits from the omics perspective.从组学角度理解复杂疾病/性状的分子数量性状基因座的研究。
Hum Genet. 2023 Nov;142(11):1543-1560. doi: 10.1007/s00439-023-02602-9. Epub 2023 Sep 27.
10
Evaluation of HLA-G 14bp Ins/Del and +3142 C/G Polymorphisms in Type 1 Diabetes among South Indian Population.印度南部人群中1型糖尿病患者HLA-G基因14bp插入/缺失及+3142 C/G多态性的评估
Indian J Endocrinol Metab. 2023 May-Jun;27(3):223-229. doi: 10.4103/ijem.ijem_7_22. Epub 2023 Jun 26.
本文引用的文献
1
MicroRNA signatures in human cancers.人类癌症中的微小RNA特征
Nat Rev Cancer. 2006 Nov;6(11):857-66. doi: 10.1038/nrc1997.
2
A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep.一种在肌肉生长抑制素基因中产生潜在异常微小RNA靶位点的突变会影响绵羊的肌肉发育。
Nat Genet. 2006 Jul;38(7):813-8. doi: 10.1038/ng1810. Epub 2006 Jun 4.
3
The Faustian bargain of genetic association studies: bigger might not be better, or at least it might not be good enough.
J Allergy Clin Immunol. 2006 Jun;117(6):1303-5. doi: 10.1016/j.jaci.2006.03.030.
4
The miscarriage-associated HLA-G -725G allele influences transcription rates in JEG-3 cells.与流产相关的HLA-G -725G等位基因影响JEG-3细胞中的转录速率。
Hum Reprod. 2006 Jul;21(7):1743-8. doi: 10.1093/humrep/del036. Epub 2006 Feb 24.
5
Evidence of balancing selection at the HLA-G promoter region.HLA-G启动子区域平衡选择的证据。
Hum Mol Genet. 2005 Dec 1;14(23):3619-28. doi: 10.1093/hmg/ddi389. Epub 2005 Oct 19.
6
Micro-RNA regulation of the mammalian lin-28 gene during neuronal differentiation of embryonal carcinoma cells.胚胎癌细胞神经元分化过程中哺乳动物lin-28基因的微小RNA调控
Mol Cell Biol. 2005 Nov;25(21):9198-208. doi: 10.1128/MCB.25.21.9198-9208.2005.
7
Sequence variants in SLITRK1 are associated with Tourette's syndrome.SLITRK1基因中的序列变异与妥瑞氏症有关。
Science. 2005 Oct 14;310(5746):317-20. doi: 10.1126/science.1116502.
8
Rethinking genetic models of asthma: the role of environmental modifiers.重新思考哮喘的遗传模型：环境修饰因子的作用。
Curr Opin Immunol. 2005 Dec;17(6):670-8. doi: 10.1016/j.coi.2005.09.009. Epub 2005 Oct 7.
9
MicroInspector: a web tool for detection of miRNA binding sites in an RNA sequence.MicroInspector：一种用于检测RNA序列中miRNA结合位点的网络工具。
Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W696-700. doi: 10.1093/nar/gki364.
10
A microRNA polycistron as a potential human oncogene.一种作为潜在人类癌基因的微小RNA多顺反子
Nature. 2005 Jun 9;435(7043):828-33. doi: 10.1038/nature03552.
Zotero 插件