Pansuriya Pramod B, Dhandhukia Pinakin, Thakkar Vasudev, Patel Mohan N
Department of Chemistry-Sardar Patel University, Vallabh Vidyanagar, 388 120 Gujarat, India.
J Enzyme Inhib Med Chem. 2007 Aug;22(4):477-87. doi: 10.1080/14756360701228988.
Five novel coordinated complexes of iron(II) with ciprofloxacin and neutral bidentate ligands have been prepared and characterized using elemental analyses, magnetic measurements, IR spectra, UV-VIS spectral, thermogravimetric analyses, 1H-NMR and 13C-NMR. The antimicrobial activity of the individual ligands, metal salt and metal complexes with respect to Bacillus subtilis, Escherichia coli, Bacillus cereus, Staphylococcus aureus, Salmonella typhi, Serratia marcescens, Aspergillus niger, Aspergillus flavus and Lasiodiplodia theobromae were evaluated by the agar-plate technique in comparison to reference standard drugs (ofloxacin, levofloxacin and fluconozole). Binding of the complexes to DNA was studied and is discussed.
