Pansuriya Pramod B, Patel M N
Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India.
J Enzyme Inhib Med Chem. 2008 Apr;23(2):230-9. doi: 10.1080/14756360701474657.
Iron(III) have been combined to well known quinolones (ciprofloxacin) and some Schiff bases with the help of coordination approach. Characterization of these compounds have been done using elemental analysis, magnetic measurements, thermogravimetric analysis, IR, UV-VIS, (1)H NMR and (13)C NMR spectral investigation. Analytical studies suggest that the iron(III)-quinolone complexes assume a six-coordinated dimeric distorted octahedral geometry. All the compounds show a good antibacterial activity against broad range of bacteria like Bacillus cereus, Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Salmonella typhi and Serratia marcescens, whereas no significant inhibition towards growth of fungal strains like Aspergillus Niger, Aspergillus flavus and Lasiodiplodia theobromae. Analyses of all these compounds show effective sperm herring DNA inhibition.
通过配位方法将铁（III）与著名的喹诺酮类药物（环丙沙星）以及一些席夫碱结合。已使用元素分析、磁性测量、热重分析、红外光谱、紫外可见光谱、（1）H核磁共振和（13）C核磁共振光谱研究对这些化合物进行了表征。分析研究表明，铁（III）-喹诺酮配合物呈现六配位二聚体扭曲八面体几何结构。所有化合物对蜡样芽孢杆菌、金黄色葡萄球菌、大肠杆菌、枯草芽孢杆菌、伤寒沙门氏菌和粘质沙雷氏菌等多种细菌均表现出良好的抗菌活性，而对黑曲霉、黄曲霉和可可毛色二孢等真菌菌株的生长没有显著抑制作用。对所有这些化合物的分析表明它们对鲱鱼精子DNA有有效的抑制作用。
