Olthoff Arno, Laskawi Rainer, Kruse Eberhard
Department of Phoniatrics and Pedaudiology, University of Göttingen, Göttingen, Germany.
Ann Otol Rhinol Laryngol. 2007 Aug;116(8):594-8. doi: 10.1177/000348940711600807.
We sought to treat autophonia due to a patulous eustachian tube using botulinum toxin.
Because we assumed that the patulous eustachian tube was caused by abnormal activity of paratubal muscles (tensor and levator veli palatini muscles and salpingopharyngeus muscle), paralysis was performed via injection of botulinum toxin type A in a 45-year-old female professional musician who had had chronic unilateral autophonia for 20 years. In addition to a patient interview, an endoscopic examination of the nasopharynx (posterior rhinoscopy), ear microscopy, and impedance audiometry were performed to verify the diagnosis and the outcome after treatment.
The autophonia disappeared 1 week after treatment. Normalized tympanic ventilation was verified by impedance audiometry after 8 weeks. The period of symptom relief was 9 months.
The administration of botulinum toxin type A provides a new option in the treatment of patulous eustachian tube. The reliability of this method and the effect of repeated injections remains to be proved in future studies.
我们试图使用肉毒杆菌毒素治疗咽鼓管异常开放引起的自听增强。
由于我们认为咽鼓管异常开放是由咽鼓管周围肌肉（腭帆张肌、腭帆提肌和咽鼓管咽肌）活动异常所致，因此对一名患有慢性单侧自听增强20年的45岁女性职业音乐家，通过注射A型肉毒杆菌毒素进行麻痹治疗。除了患者访谈外，还进行了鼻咽内镜检查（后鼻镜检查）、耳镜检查和阻抗测听，以核实诊断和治疗后的结果。
治疗1周后自听增强消失。8周后通过阻抗测听证实鼓膜通气恢复正常。症状缓解期为9个月。
A型肉毒杆菌毒素的应用为咽鼓管异常开放的治疗提供了一种新选择。该方法的可靠性以及重复注射的效果有待未来研究证实。
