Mahmoud Mohamad S, Merhi Zaher O, Yelian Frank D
Departments of Obstetrics and Gynecology, Oakwood Hospital and Medical Center, Dearborn, and Wayne State University School of Medicine, Detroit, Michigan, USA.
J Reprod Med. 2007 Jul;52(7):623-9.
To present an overview of the potential etiologies of premature ovarian failure (POF), with an emphasis on the chromosomal abnormalities, gene mutations and autoimmune disorders.
This article is based on a literature review of articles on POF using PubMed and MEDLINE for the years 1966-2005 using the keywords premature ovarian failure, trying to ascertain the possible mechanisms of POF reported to date.
The etiology of POF is still under investigation, even though a wide range of etiologies has been unveiled, encompassing genetic mutations, chromosomal abnormalities, autoimmune disorders, and iatrogenic (irradiation, chemotherapy) and idiopathic causes.
In the majority of POF cases, the etiology remains subtle.
概述卵巢早衰（POF）的潜在病因，重点关注染色体异常、基因突变和自身免疫性疾病。
本文基于对1966 - 2005年期间使用PubMed和MEDLINE数据库、以“卵巢早衰”为关键词检索到的关于POF的文献进行综述，旨在确定迄今报道的POF可能机制。
尽管已揭示出多种病因，包括基因突变、染色体异常、自身免疫性疾病、医源性（辐射、化疗）及特发性病因，但POF的病因仍在研究中。
在大多数POF病例中，病因仍不明确。
