Nippita T A, Baber R J
Department of Obstetrics and Gynaecology, Royal North Shore Hospital, St Leonards, and The University of Sydney, Australia.
Climacteric. 2007 Feb;10(1):11-22. doi: 10.1080/13697130601135672.
To present an updated review on the etiology, consequences and management of premature ovarian failure.
A search of the English language literature using the Cochrane Library database and Medline 1966-2006, with a hand search of the references.
Premature ovarian failure is defined as the occurrence of amenorrhea, hypergonadotropinemia and estrogen deficiency in women under the age of 40 years, with the prevalence being 0.9-1.2%. In the majority of cases, the etiology is unknown, but known causes include chemotherapy, radiotherapy, surgery, genetic disorders, particularly involving the X chromosome, associations with autoimmune diseases, infections, smoking and other toxins. The three critical issues of management in these women are the effect of the diagnosis on the psychological health of the patient, the consequent infertility and the long- and short-term effects of estrogen deficiency arising from ovarian decline. Promising methods of screening for premature ovarian failure are being developed.
对卵巢早衰的病因、后果及管理进行最新综述。
使用考克兰图书馆数据库和1966 - 2006年的医学期刊数据库检索英文文献，并人工检索参考文献。
卵巢早衰定义为40岁以下女性出现闭经、高促性腺激素血症和雌激素缺乏，患病率为0.9 - 1.2%。在大多数情况下，病因不明，但已知病因包括化疗、放疗、手术、遗传疾病，特别是涉及X染色体的疾病、与自身免疫性疾病的关联、感染、吸烟及其他毒素。这些女性管理中的三个关键问题是诊断对患者心理健康的影响、随之而来的不孕以及卵巢功能衰退导致的雌激素缺乏的长期和短期影响。正在开发有前景的卵巢早衰筛查方法。
