Bojić Lovro, Rogosić Veljko, Ivanisević Milan, Matijaca Meri, Lusić Ivo, Pintarić Irena, Vrebalov-Cindro Veselin, Racić Goran
Department of Ophthalmology, University Hospital "Split", Split, Croatia.
Coll Antropol. 2007 Jun;31(2):557-60.
The aim of this study was to determine the incidence of monosymptomatic optic neuritis (MON) and progression of MON to multiple sclerosis (MS) from the Mediterranean region of southern Europe in the County of Split-Dalmatia, Croatia during the 11 years period from 1991 to 2001. This study was made retrospectively on the 87 cases (59 female, aged 25.9 +/- 11.3 and 28 male aged 29.9 +/- 9.2) of MON, which were treated at the Department of Ophthalmology and Department of Neurology, Split, University Hospital, from January 1991 to December 2001. In each case the diagnosis was confirmed by a chart review and cases were ascribed to the data of admittance at hospital. The annual incidence of MON was 1.9 per 100,000 (95% CI, 0.4-3.5). The incidence among males was 1.2 (95% CI, 0-2.9) cases / 100,000 per year and 2.5 (95% CI, 0.1-4.9) among females. A significant seasonal variations in the incidence of MON was not found (chi2 = 6.81, p = 0.08). MS developed in 20 of 87 patients (22.9%) and median time was 25 (SE 8) months, (95% CI, 9-41) after the MON onset. After two years 12.6% of patients with MON developed MS, 20.6% after 5 years and 22.9% after 10 years. MS was slightly but not significantly more frequent in women than in men (chi2 = 0.72, p = 0.3). In conclusion, the progression of MON to MS in the County of Split-Dalmatia, Croatia was at a relatively moderate frequency.
本研究的目的是确定1991年至2001年这11年间，克罗地亚斯普利特-达尔马提亚县南欧地中海地区单症状性视神经炎（MON）的发病率以及MON进展为多发性硬化症（MS）的情况。本研究对1991年1月至2001年12月期间在斯普利特大学医院眼科和神经科接受治疗的87例MON患者（59例女性，年龄25.9±11.3岁；28例男性，年龄29.9±9.2岁）进行了回顾性研究。每例患者均通过病历审查确诊，并根据入院数据进行归类。MON的年发病率为每10万人1.9例（95%可信区间，0.4 - 3.5）。男性发病率为每年每10万人1.2例（95%可信区间，0 - 2.9），女性为2.5例（95%可信区间，0.1 - 4.9）。未发现MON发病率有显著的季节性变化（χ2 = 6.81，p = 0.08）。87例患者中有20例（22.9%）发展为MS，中位时间为MON发病后25（标准误8）个月（95%可信区间，9 - 41）。两年后，12.6%的MON患者发展为MS，5年后为20.6%，10年后为22.9%。MS在女性中的发生率略高于男性，但无显著差异（χ2 = 0.72，p = 0.3）。总之，在克罗地亚斯普利特-达尔马提亚县，MON进展为MS的频率相对适中。
