Buters Jeroen T M, Kasche Anna, Weichenmeier Ingrid, Schober Wolfgang, Klaus Sabrina, Traidl-Hoffmann Claudia, Menzel Annette, Huss-Marp Johannes, Kramer Ursula, Behrendt Heidrun
Division of Environmental Dermatology and Allergy GSF/TUM, ZAUM-Center for Allergy and Environment, Technical University Munich, Munich, Germany.
Int Arch Allergy Immunol. 2008;145(2):122-30. doi: 10.1159/000108137. Epub 2007 Sep 10.
The release of the aeroallergen Bet v 1 from pollen is a major determinant in the etiology of allergic airway disease due to birch pollen.
We determined the release of the major birch pollen allergen Bet v 1 from pollen of birch trees growing in 2 different geographic regions in Germany for 2 consecutive years.
Catkins were collected during pollination in 2002 and 2003 from 82 healthy trees in South (Munich) and West Germany (North Rhine-Westphalia). The release of Bet v 1 from pollen samples was determined by a Bet v 1-specific ELISA.
Pollen from South Germany released about 3 times more Bet v 1 than those from West Germany in both 2002 and 2003 (p = 0.034 and p = 0.007, respectively). This was independent of the number of pollen during the pollen flight season. In 2003, the release of Bet v 1 from pollen was more than 5 times higher than in 2002 in both regions (South Germany 6.1 times, p < 0.001; West Germany 5.4 times, p = 0.003).
Despite large individual differences, there seem to be regional and year-to-year variations in Bet v 1 release from birch pollen. Therefore, the combination of pollen count and release of Bet v 1 from this pollen must be assessed to estimate Bet v 1 exposure reliably.
气传变应原Bet v 1从花粉中的释放是桦树花粉所致变应性气道疾病病因学中的一个主要决定因素。
我们连续两年测定了生长于德国2个不同地理区域的桦树花粉中主要变应原Bet v 1的释放情况。
在2002年和2003年授粉期间，从德国南部（慕尼黑）和西部（北莱茵-威斯特法伦州）的82株健康桦树上采集柔荑花序。通过Bet v 1特异性酶联免疫吸附测定法（ELISA）测定花粉样本中Bet v 1的释放量。
2002年和2003年，德国南部花粉释放的Bet v 1比德国西部的约多3倍（p值分别为0.034和0.007）。这与花粉传播季节的花粉数量无关。2003年，两个地区花粉中Bet v 1的释放量均比2002年高出5倍多（德国南部为6.1倍，p<0.001；德国西部为5.4倍，p = 0.003）。
尽管存在较大的个体差异，但桦树花粉中Bet v 1的释放似乎存在地区和逐年差异。因此，必须评估花粉计数以及该花粉中Bet v 1的释放量，以可靠地估计Bet v 1暴露情况。
