Frick Inga-Maria, Björck Lars, Herwald Heiko
Section for Clinical and Experimental Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden.
Thromb Haemost. 2007 Sep;98(3):497-502.
Hemostasis is a sensitive and tightly regulated process, involving the vascular endothelium and blood cells as well as factors of the coagulation and fibrinolytic cascades. Over the last four decades evidence has accumulated that during infection, inflammatory mediators from the microbe and/or host are capable to modulate the equilibrium between the procoagulant and anticoagulant status of the host. Dependent on the mode of activation, these changes can cause either local or systemic inflammatory reactions that may be beneficial or deleterious to the human host. The present review aims to present the state of the art with respect to the role of the contact system (also known as the intrinsic pathway of coagulation or the kallikrein/kinin system) in innate immunity and systemic inflammatory reactions.
止血是一个敏感且受到严格调控的过程，涉及血管内皮、血细胞以及凝血和纤维蛋白溶解级联反应的各种因子。在过去的四十年里，越来越多的证据表明，在感染期间，来自微生物和/或宿主的炎症介质能够调节宿主促凝和抗凝状态之间的平衡。根据激活方式的不同，这些变化可引发局部或全身炎症反应，对人类宿主可能有益也可能有害。本综述旨在介绍接触系统（也称为内源性凝血途径或激肽释放酶/激肽系统）在先天免疫和全身炎症反应中的作用的最新研究进展。
