Rivera Jose, Vannakambadi Ganesh, Höök Magnus, Speziale Pietro
CEMB, Institute of Biosciences and Technology, 2121 W. Holcombe, Houston, Texas 77030, USA.
Thromb Haemost. 2007 Sep;98(3):503-11.
Fibrinogen (Fg), the major clotting protein in blood plasma, plays key roles in blood coagulation and thrombosis. In addition, this 340 kD glycoprotein is a stress inducible protein; its synthesis is dramatically upregulated during inflammation or under exposure to stress such systemic infections. This regulation of Fg expression indicates that Fg also participates in the host defense system against infections. In fact, a number of reported studies have demonstrated the involvement of both the intrinsic and extrinsic pathways of coagulation; the thrombotic and the fibrinolytic systems in the pathophysiology of infectious diseases. It is, therefore, perhaps not surprising that many pathogenic bacteria can interact with Fg and manipulate its biology. This review focuses on the major Fg-binding proteins (Fgbps) from Gram-positive bacteria with an emphasis on those that are known to have an effect on coagulation and thrombosis.
纤维蛋白原（Fg）是血浆中的主要凝血蛋白，在血液凝固和血栓形成中起关键作用。此外，这种340kD的糖蛋白是一种应激诱导蛋白；在炎症期间或暴露于全身性感染等应激状态下，其合成会显著上调。Fg表达的这种调节表明Fg也参与宿主抗感染防御系统。事实上，许多已报道的研究表明凝血的内源性和外源性途径、血栓形成和纤维蛋白溶解系统都参与了传染病的病理生理学过程。因此，许多病原菌能够与Fg相互作用并操纵其生物学特性或许并不令人惊讶。本综述重点关注革兰氏阳性菌的主要Fg结合蛋白（Fgbps），尤其侧重于那些已知对凝血和血栓形成有影响的蛋白。
