Nitsche-Schmitz D Patric, Rohde Manfred, Chhatwal Gursharan S
Helmholtz Centre for Infection Research, Microbial Pathogenesis, Braunschweig, Germany.
Thromb Haemost. 2007 Sep;98(3):488-96.
Gram-positive cocci are important human pathogens. Streptococci and staphylococci in particular are a major threat to human health, since they cause a variety of serious invasive infections. Their invasion into normally sterile sites of the host depends on elaborated bacterial mechanisms that involve adhesion to the host tissue, its degradation, internalisation by host cells, and passage through epithelia and endothelia. Interactions of bacterial surface proteins with proteins of the host's extracellular matrix as well as with cell surface receptors are crucial factors in these processes, and some of the key mechanisms are similar in many pathogenic Gram-positive cocci. Therapies that interfere with these mechanisms may become efficient alternatives to today's antibiotic treatments.
革兰氏阳性球菌是重要的人类病原体。特别是链球菌和葡萄球菌，它们对人类健康构成重大威胁，因为它们会引发多种严重的侵袭性感染。它们侵入宿主通常无菌的部位依赖于复杂的细菌机制，这些机制包括与宿主组织的黏附、组织降解、被宿主细胞内化以及穿过上皮细胞和内皮细胞。细菌表面蛋白与宿主细胞外基质蛋白以及细胞表面受体的相互作用是这些过程中的关键因素，并且一些关键机制在许多致病性革兰氏阳性球菌中是相似的。干扰这些机制的疗法可能会成为当今抗生素治疗的有效替代方案。
