Aepfelbacher Martin, Trasak Claudia, Ruckdeschel Klaus
Institut für Medizinische Mikrobiologie, Virologie und Hygiene, Diagnostikzentrum, Universitätsklinikum Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.
Thromb Haemost. 2007 Sep;98(3):521-9.
Pathogenic species of the genus Yersinia suppress and reorient the immune system to infect lymphatic tissues, inner organs and at times also the vasculature. For this purpose yersiniae employ a type III secretion system to translocate effector proteins (Yersinia outer proteins; Yops) into immune cells. Yops often exert unique biochemical activities for modulating the activity of Rho GTP-binding proteins, focal adhesion proteins, inflammatory pathways and cell survival/apoptosis. In this review we will put emphasis on the biochemistry, cell- and infection biology of Yersinia effector Yops.
耶尔森氏菌属的致病物种会抑制并重新定向免疫系统，以感染淋巴组织、内部器官，有时还会感染脉管系统。为此，耶尔森氏菌利用III型分泌系统将效应蛋白（耶尔森氏菌外蛋白；Yops）转运到免疫细胞中。Yops通常具有独特的生化活性，可调节Rho GTP结合蛋白、粘着斑蛋白、炎症信号通路以及细胞存活/凋亡的活性。在本综述中，我们将重点关注耶尔森氏菌效应蛋白Yops的生物化学、细胞生物学和感染生物学。
