Ito Yoko, Betsuyaku Tomoko, Nasuhara Yasuyuki, Nishimura Masaharu
First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
Exp Lung Res. 2007 Sep;33(7):375-84. doi: 10.1080/01902140701634843.
In aged humans and animals, lung injuries are generally more serious and prolonged. From a kinetic perspective, the authors thus assessed whether lung expression of proinflammatory cytokines were altered with age following intratracheal lipopolysaccharide (LPS) challenge in mice. Tumor necrosis factor-alpha, interleukin-1beta, macrophage inflammatory protein-1alpha, macrophage inflammatory protein-2, and keratinocyte-derived chemokine were significantly higher in 65-week-old mice along with sustained neutrophilia when compared to 11-week-old mice at 72 hours, but not at earlier time points. The authors concluded that the degree of LPS-induced neutrophilic inflammation and the expression of these cytokines differ with age at later phases of acute lung injury.
在老年人类和动物中，肺部损伤通常更严重且持续时间更长。因此，从动力学角度来看，作者评估了在小鼠气管内注射脂多糖（LPS）后，促炎细胞因子的肺部表达是否会随年龄而改变。与11周龄小鼠相比，65周龄小鼠在72小时时肿瘤坏死因子-α、白细胞介素-1β、巨噬细胞炎性蛋白-1α、巨噬细胞炎性蛋白-2和角质形成细胞衍生趋化因子显著更高，同时伴有持续性嗜中性粒细胞增多，但在更早时间点则没有。作者得出结论，在急性肺损伤后期，LPS诱导的嗜中性粒细胞炎症程度和这些细胞因子的表达随年龄而异。
