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包膜蛋白Us9是牛疱疹病毒1型在重新激活时从三叉神经节向鼻和眼进行顺行运输所必需的。

Envelope protein Us9 is required for the anterograde transport of bovine herpesvirus type 1 from trigeminal ganglia to nose and eye upon reactivation.

作者信息

Butchi N B, Jones C, Perez S, Doster A, Chowdhury S I

机构信息

Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA.

出版信息

J Neurovirol. 2007 Aug;13(4):384-8. doi: 10.1080/13550280701375433.

DOI:10.1080/13550280701375433
PMID:17849322
Abstract

In this study, the authors examined the role of bovine herpesvirus type 1 (BHV-1) Us9 in the anterograde transport of the virus from trigeminal ganglia (TG) to nose and eye upon reactivation from latency. During primary infection, both BHV-1 Us9-deleted and BHV-1 Us9-rescued viruses replicated efficiently in the nasal and ocular epithelium. However, upon reactivation from latency, only the BHV-1 Us9-rescued virus could be isolated in the nasal and ocular shedding. By real-time polymerase chain reaction, comparable DNA copy numbers were detected in the TGs during latency and reactivation for both the viruses. Therefore, Us9 is essential for reactivation of the virus in the TG and anterograde axonal transport from TG to nose and eye.

摘要

在本研究中，作者检测了牛疱疹病毒1型（BHV-1）的Us9在病毒从三叉神经节（TG）潜伏激活后向鼻和眼的顺行运输中的作用。在初次感染期间，缺失BHV-1 Us9的病毒和拯救了BHV-1 Us9的病毒均能在鼻和眼上皮中高效复制。然而，在潜伏激活后，仅能在鼻和眼分泌物中分离到拯救了BHV-1 Us9的病毒。通过实时聚合酶链反应，在两种病毒的潜伏和激活期间，TG中检测到的DNA拷贝数相当。因此，Us9对于病毒在TG中的激活以及从TG到鼻和眼的轴突顺行运输至关重要。

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The Us9 gene of bovine herpesvirus 1 (BHV-1) effectively complements a Us9-null strain of BHV-5 for anterograde transport, neurovirulence, and neuroinvasiveness in a rabbit model.牛疱疹病毒1型（BHV-1）的Us9基因可有效补充BHV-5的Us9缺失株，用于兔模型中的顺行运输、神经毒力和神经侵袭性研究。
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Concurrent Gene Insertion, Deletion, and Inversion during the Construction of a Novel Attenuated BoHV-1 Using CRISPR/Cas9 Genome Editing.使用CRISPR/Cas9基因组编辑构建新型减毒牛疱疹病毒1型过程中的并发基因插入、缺失和倒位
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