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成人肾母细胞瘤:一例病例报告及文献综述

Wilms' tumour in adults: a case report and review of the literature.

作者信息

Gallagher D J, Duffy A, McCaffrey J

机构信息

Department of Medical Oncology, Mater Misercordiae University Hospital, Eccles St, Dublin 7, Ireland.

出版信息

Ir J Med Sci. 2007 Mar;176(1):49-51. doi: 10.1007/s11845-007-0012-3.

Abstract

BACKGROUND

Wilms' tumour is a very rare adult malignancy representing 1% of adult renal tumours. It is however the most common renal tumour of childhood, and adult patients are treated in accordance with paediatric protocols.

AIM

To review modern day management of adult Wilms' tumour.

METHODS

We report a case of adult Wilms' tumour and discuss the management including the use of newer treatment modalities.

RESULTS

Following diagnostic nephrectomy, our patient was treated with chemotherapy in accordance with North American paediatric protocols and PET scanning was used to diagnose early relapse.

CONCLUSION

In the absence of randomised controlled data, central reporting of cases of adult Wilms' Tumour may help improve management. The incorporation of newer chemotherapeutic agents, high-dose therapy and PET scanning into treatment protocols should improve outcome for these patients.

摘要

背景

肾母细胞瘤是一种非常罕见的成人恶性肿瘤,占成人肾肿瘤的1%。然而,它是儿童期最常见的肾肿瘤,成年患者按照儿科治疗方案进行治疗。

目的

回顾成人肾母细胞瘤的现代治疗方法。

方法

我们报告一例成人肾母细胞瘤病例,并讨论其治疗方法,包括使用更新的治疗方式。

结果

在诊断性肾切除术后,我们的患者按照北美儿科治疗方案接受化疗,并使用PET扫描诊断早期复发。

结论

在缺乏随机对照数据的情况下,对成人肾母细胞瘤病例进行集中报告可能有助于改善治疗。将更新的化疗药物、高剂量治疗和PET扫描纳入治疗方案应能改善这些患者的治疗效果。

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