Vakili Rahim, Hiradfar Mehran, Zabolinejad Nona, Badiei Zahra
Department of Pediatric Endocrinology, Mashhad University of Medical Sciences, Mashhad, Iran.
J Pediatr Endocrinol Metab. 2007 Jul;20(7):841-5. doi: 10.1515/jpem.2007.20.7.841.
Tumor-induced hypercalcemia is a frequent complication of advanced cancers, but it has been rarely reported in patients with sarcoma. We report a 16 year-old boy presenting with polyuria, polydipsia and severe dehydration. Laboratory examination revealed severe hypercalcemia (serum calcium 23 mg/dl) which caused emaciation and was accompanied by low serum phosphorus and suppressed parathyroid hormone. Diagnostic imaging revealed a huge anterior mediastinal mass. Hypercalcemia was successfully treated with pamidronate, a bisphosphonate, and the patient underwent surgical resection. Pathological and immunohistochemical analyses confirmed a diagnosis of biphasic synovial sarcoma. To our knowledge, this is the first case of mediastinal synovial sarcoma presenting with hypercalcemia.
肿瘤诱导的高钙血症是晚期癌症常见的并发症，但在肉瘤患者中鲜有报道。我们报告一名16岁男孩，表现为多尿、烦渴和严重脱水。实验室检查显示严重高钙血症（血清钙23mg/dl），导致消瘦，并伴有低血清磷和甲状旁腺激素抑制。诊断性影像学检查发现前纵隔巨大肿块。高钙血症通过双膦酸盐帕米膦酸成功治疗，患者接受了手术切除。病理和免疫组化分析确诊为双相滑膜肉瘤。据我们所知，这是首例伴有高钙血症的纵隔滑膜肉瘤病例。
