Donauer Johannes
Abteilung fir Nephrologie und Allgemeinmedizin, Universitätsklinik Freiburg.
MMW Fortschr Med. 2007 Aug 2;149(31-32):27-8.
Until recently, living kidney donations between donors and recipients of different blood groups were contraindicated. Since 2004, blood group incompatible kidney transplantations have been performed in Germany. Through the use of the anti-CD20 antibody rituximab and a highly selective immunoadsorption treatment, the recipient's antibodies against the foreign blood group are removed before the transplantation to minimize the risk of an antibody-mediated acute rejection reaction after the transplantation.
直到最近，不同血型的供体和受体之间进行活体肾捐赠仍是禁忌。自2004年以来，德国已开展了血型不相容的肾移植手术。通过使用抗CD20抗体利妥昔单抗和高度选择性免疫吸附治疗，在移植前去除受者针对外来血型的抗体，以将移植后抗体介导的急性排斥反应风险降至最低。
