Klepac R, Milković K
Endokrinologie. 1975 Sep;66(1):74-80.
The effects of growth hormone and ACTH, alone or in combination, on fetal rat adrenal steroidogenesis in vitro were examined on the last day of intrauterine development. ACTH increased, while growth hormone did not affect fetal adrenal weight. ACTH increased fetal rat adrenal steroidogenesis, hydroxylation of 4-14C-progesterone to corticosterone, 18-hydroxy-11-deoxycorticosterone, 11-hydroxycorticosterone and aldosterone. Growth hormone alone had no effect on fetal adrenal steroidogenesis. ACTH and growth hormone administered together increased the conversion of progesterone to the above mentioned steroids to a greater extent than ACTH alone. The results indicate that growth hormone may participate in the fetal rat adrenal steroidogenesis potentiating the effects of fetal pituitary ACTH.
在子宫内发育的最后一天，研究了生长激素和促肾上腺皮质激素单独或联合使用对体外培养的胎鼠肾上腺类固醇生成的影响。促肾上腺皮质激素增加了胎鼠肾上腺重量，而生长激素则无此作用。促肾上腺皮质激素增加了胎鼠肾上腺类固醇生成，使4-¹⁴C-孕酮羟基化为皮质酮、18-羟基-11-脱氧皮质酮、11-羟基皮质酮和醛固酮。单独使用生长激素对胎鼠肾上腺类固醇生成无影响。促肾上腺皮质激素和生长激素联合使用比单独使用促肾上腺皮质激素能更大程度地增加孕酮向上述类固醇的转化。结果表明，生长激素可能参与胎鼠肾上腺类固醇生成，增强胎儿垂体促肾上腺皮质激素的作用。
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