分子内钯催化的烯基三氟甲磺酸酯直接芳基化反应。
Intramolecular palladium-catalyzed direct arylation of alkenyl triflates.
作者信息
Cruz Ana C F, Miller Neil D, Willis Michael C
机构信息
Department of Chemistry, University of Bath, Bath, BA2 7AY, UK.
出版信息
Org Lett. 2007 Oct 11;9(21):4391-3. doi: 10.1021/ol702044z. Epub 2007 Sep 13.
PMID:17850159
Abstract
A catalyst generated from Pd(OAc)2 and dppp is effective for the direct intramolecular arylation of alkenyl triflates. Conjugated alkene-arene-containing carbocycles are produced in good yield. The process tolerates a variety of aryl substituents as well a simple heteroaryl groups. Electron-deficient aryl rings deliver faster reactions.
摘要
由醋酸钯（Pd(OAc)₂）和1,3-双(二苯基膦基)丙烷（dppp）生成的催化剂对烯基三氟甲磺酸酯的直接分子内芳基化反应有效。含共轭烯烃-芳烃的碳环以良好的产率生成。该反应过程能耐受多种芳基取代基以及简单的杂芳基。缺电子芳环的反应速度更快。
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