钯催化的芳基三氟甲磺酸酯的串联直接芳基化/N-芳基化合成蝙蝠葛碱和 NK109。
Formal synthesis of nitidine and NK109 via palladium-catalyzed domino direct arylation/N-arylation of aryl triflates.
机构信息
Davenport Research Laboratories, Department of Chemistry, University of Toronto, Toronto, Ontario, Canada, M5S 3H6.
出版信息
Org Lett. 2011 Mar 18;13(6):1486-9. doi: 10.1021/ol200174g. Epub 2011 Feb 24.
PMID:21348508
Abstract
The use of aryl triflates as reaction partners in a palladium-catalyzed domino direct arylation/N-arylation provides a great advantage due to the availability of starting materials. Furthermore, it allows expedient access to biologically interesting benzo[c]phenanthridine alkaloids.
摘要
芳基三氟甲磺酸酯作为钯催化的多米诺直接芳基化/N-芳基化反应的反应伙伴具有很大的优势，因为其起始原料易得。此外，它还可以方便地获得具有生物活性的苯并[c]菲啶生物碱。
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