Joe Keun-Ho, Kim Yong-Ku, Kim Tae-Suk, Roh Sung-Won, Choi Sam-Wook, Kim Young-Bo, Lee Hee-Jin, Kim Dai-Jin
Department of Social Welfare with Addiction Rehabilitation, Eulji University, Daejeon, Korea.
Alcohol Clin Exp Res. 2007 Nov;31(11):1833-8. doi: 10.1111/j.1530-0277.2007.00507.x. Epub 2007 Sep 11.
Many reports have suggested possible relationships between brain-derived neurotrophic factor (BDNF) and alcohol dependence. A protective effect of BDNF against ethanol-induced cell damage has been suggested, and this effect may contribute to the development or maintenance of alcohol dependence. This study was carried out in order to verify the significance of BDNF in alcohol dependence.
Peripheral BDNF levels were measured in alcohol-dependent patients and control subjects using an enzyme-linked immunosorbent assay. A physician's interview and standardized questionnaire were used to obtain information regarding each patient's history of alcohol consumption.
The mean BDNF level was lower in the alcohol dependence group (389.5 +/- 501.7 pg/ml) than in the normal controls (822.5 +/- 420.7 pg/ml) by analysis of covariance (ANCOVA) (F = 25.79, p < 0.01). The mean BDNF level was lower in the alcohol-dependent patients with a positive family history of alcohol dependence (247.6 +/- 289.2 pg/ml) than in those with a negative family history of alcohol dependence (583.9 +/- 652.8 pg/ml) by ANCOVA (F = 6.51, p = 0.01). The BDNF levels did not correlate significantly with any of the variables analyzed in this study, including Beck depression inventory, state and trait anxiety inventory (STAI-S and T), and various drinking behaviors.
Changes in the levels of BDNF might play a role in the pathophysiology and inheritance of alcohol dependence.
许多报告表明脑源性神经营养因子（BDNF）与酒精依赖之间可能存在关联。已有研究提示BDNF对乙醇诱导的细胞损伤具有保护作用，且这种作用可能有助于酒精依赖的发生或维持。本研究旨在验证BDNF在酒精依赖中的意义。
采用酶联免疫吸附测定法测量酒精依赖患者和对照受试者外周血BDNF水平。通过医生访谈和标准化问卷获取每位患者饮酒史的相关信息。
通过协方差分析（ANCOVA）发现，酒精依赖组的平均BDNF水平（389.5±501.7 pg/ml）低于正常对照组（822.5±420.7 pg/ml）（F = 25.79，p < 0.01）。通过ANCOVA分析，有酒精依赖家族史的酒精依赖患者平均BDNF水平（247.6±289.2 pg/ml）低于无酒精依赖家族史的患者（583.9±652.8 pg/ml）（F = 6.51，p = 0.01）。BDNF水平与本研究分析的任何变量均无显著相关性，这些变量包括贝克抑郁量表、状态和特质焦虑量表（STAI-S和T）以及各种饮酒行为。
BDNF水平的变化可能在酒精依赖的病理生理学和遗传中起作用。
