Allweiler Sandra, Brodbelt David C, Borer Kate, Hammond Richard A, Alibhai Hatim I K
Royal Veterinary College, Hatfield, UK.
Vet Anaesth Analg. 2007 Nov;34(6):388-93. doi: 10.1111/j.1467-2995.2006.00308.x. Epub 2007 Sep 7.
To evaluate the isoflurane-sparing and clinical effects of two constant rate infusions of remifentanil in healthy dogs undergoing orthopaedic surgery.
Prospective, randomized clinical study.
Forty-one American Society of Anesthesiologists I-II client-owned dogs (age, 7 months-9 years; body mass 11-59 kg).
Dogs were randomly assigned to one of three groups and received either: intramuscular (IM) meperidine 2 mg kg(-1) every 2 hours throughout surgery (control group (C); n = 13); remifentanil infused intravenously (IV) at 0.1 microg kg(-1) minute(-1) (low remifentanil group (L); n = 14) or remifentanil infused at 0.25 microg kg(-1) minute(-1) IV (high remifentanil group (H); n = 14). Anaesthesia was induced with thiopental administered to effect and maintained using isoflurane in 100% oxygen. During controlled ventilation when the end-tidal CO(2) was maintained between 4.65 and 5.98 kPa [35-45 mmHg], the end-tidal isoflurane concentration (e'iso%), mean arterial blood pressure (MAP) and heart rate (HR) were measured every 5 minutes. Bradycardia (HR < 40 minute(-1) lasting >5 minutes) was corrected with 0.01 mg kg(-1) IV glycopyrrolate. Data were analysed using the Kruskal-Wallis test with a post-hoc Mann-Whitney U-test and Bonferroni correction. Statistical significance was accepted at < or = 0.05. Data are expressed as mean +/- standard deviation.
The e'iso% was reduced in a dose-dependent manner by remifentanil. In C, e'iso% was 1.28 +/-0.13 and was significantly different from L (0.78 +/- 0.17, p < 0.001) and H (0.65 +/- 0.16, p < 0.001). HR was significantly different between groups (p < 0.001). There were no significant differences in MAP between groups. Glycopyrrolate was required in two, three and six dogs in the C, L and H groups respectively.
Remifentanil infusion reduced the isoflurane concentration required for surgical anaesthesia during orthopaedic surgery.
Remifentanil infusions may be a useful additive to isoflurane anaesthesia in healthy dogs.
评估在接受骨科手术的健康犬中，两种恒速输注瑞芬太尼对异氟烷的节省作用及临床效果。
前瞻性、随机临床研究。
41只美国麻醉医师协会I-II级客户拥有的犬（年龄7个月至9岁；体重11至59千克）。
犬被随机分为三组之一，分别接受：整个手术过程中每2小时肌肉注射（IM）哌替啶2毫克/千克（对照组（C）；n = 13）；静脉输注（IV）瑞芬太尼0.1微克/千克/分钟（低剂量瑞芬太尼组（L）；n = 14）或静脉输注瑞芬太尼0.25微克/千克/分钟（高剂量瑞芬太尼组（H）；n = 14）。用硫喷妥钠诱导麻醉至起效，并使用异氟烷和100%氧气维持麻醉。在控制通气期间，当呼气末二氧化碳维持在4.65至5.98千帕[35至45毫米汞柱]之间时，每5分钟测量呼气末异氟烷浓度（e'iso%）、平均动脉血压（MAP）和心率（HR）。心动过缓（HR < 40次/分钟持续>5分钟）用0.01毫克/千克静脉注射格隆溴铵纠正。数据采用Kruskal-Wallis检验及事后Mann-Whitney U检验和Bonferroni校正进行分析。统计学显著性以p≤0.05接受。数据以平均值±标准差表示。
瑞芬太尼以剂量依赖性方式降低了e'iso%。在C组中，e'iso%为1.28±0.13，与L组（0.78±0.17，p < 0.001）和H组（0.65±0.16，p < 0.001）有显著差异。组间HR有显著差异（p < 0.001）。组间MAP无显著差异。C组、L组和H组分别有2只、3只和6只犬需要使用格隆溴铵。
输注瑞芬太尼降低了骨科手术中手术麻醉所需的异氟烷浓度。
在健康犬中，输注瑞芬太尼可能是异氟烷麻醉的一种有用辅助药物。
