Henao-Guerrero Piedad N, McMurphy Rose, Kukanich Butch, Hodgson Dave S
Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Vet Anaesth Analg. 2009 Mar;36(2):133-43. doi: 10.1111/j.1467-2995.2008.00440.x.
To assess the effect of morphine on the bispectral index (BIS) in dogs during isoflurane anesthesia maintained at a constant end-tidal concentration.
Prospective, randomized, experimental trial.
Eight adult Beagle dogs, weighing between 7.1 and 9.8 kg.
Anesthesia was induced with isoflurane via a face mask. Dog's tracheas were intubated and anesthesia maintained with isoflurane at a constant end-tidal concentration (e'Iso) of 1.81% for a 30-minute equilibration period. Pulmonary ventilation was controlled to normocapnia. After equilibration, baseline values were recorded prior to intravenous administration of morphine sulfate (0.5 mg kg(-1)) (MT) or an equal volume of saline (CT). Measurements for heart rate, systolic, diastolic and mean arterial pressure (SAP, DAP and MAP) were recorded at 10, 20, 30, 45, 60, 75, 90, 105 and 120 minutes after treatment. Bispectral index was recorded every 10 seconds for 3 minutes for each time measurement. Venous blood samples were collected at baseline, 10, 20, 30, 45, 60 and 120 minutes for determination of morphine serum concentrations. Anesthesia was discontinued after the last measurement and dogs were allowed to recover.
Baseline BIS for MT and CT at 1.81%e'Iso were 63 +/- 10 and 58 +/- 9, respectively. Bispectral index in MT was 4-8% lower at 20, 75, 90 and 105 minutes compared with CT. There were no differences in BIS between baseline and any subsequent measurement within either MT or CT. Heart rate, SAP, MAP, and DAP decreased after morphine administration.
Intravenous administration of 0.5 mg kg(-1) morphine sulfate did not cause clinically significant changes in the BIS of unstimulated dogs during isoflurane anesthesia at an e'Iso of 1.81%.
评估在异氟烷麻醉维持于恒定呼气末浓度期间吗啡对犬脑电双频指数（BIS）的影响。
前瞻性、随机、实验性试验。
8只成年比格犬，体重在7.1至9.8千克之间。
通过面罩用异氟烷诱导麻醉。对犬进行气管插管，并用异氟烷维持麻醉，呼气末浓度（e'Iso）恒定为1.81%，平衡期为30分钟。控制肺通气以维持正常碳酸血症。平衡后，在静脉注射硫酸吗啡（0.5毫克/千克）（MT组）或等体积生理盐水（CT组）之前记录基线值。在治疗后10、20、30、45、60、75、90、105和120分钟记录心率、收缩压、舒张压和平均动脉压（SAP、DAP和MAP）。每次测量时，每10秒记录一次BIS，持续3分钟。在基线、10、20、30、45、60和120分钟采集静脉血样以测定吗啡血清浓度。最后一次测量后停止麻醉，让犬恢复。
在1.81%e'Iso时，MT组和CT组的基线BIS分别为63±10和58±9。与CT组相比，MT组在20、75、90和105分钟时的BIS低4 - 8%。MT组或CT组内基线与任何后续测量之间的BIS无差异。注射吗啡后心率、SAP、MAP和DAP降低。
在e'Iso为1.81%的异氟烷麻醉期间，静脉注射0.5毫克/千克硫酸吗啡未引起未受刺激犬的BIS发生临床显著变化。
