自体输血对前列腺癌根治术后生化复发率的影响。
Effect of autologous blood transfusion on the rate of biochemical recurrence after radical prostatectomy.
作者信息
Gallina Andrea, Briganti Alberto, Chun Felix K-H, Walz Jochen, Hutterer Georg C, Erbersdobler Andreas, Eichelberg Christian, Schlomm Thorsten, Ahyai Sascha A, Perrotte Paul, Saad Fred, Montorsi Francesco, Huland Hartwig, Graefen Markus, Karakiewicz Pierre I
机构信息
Department of Urology, Vita-Salute University San Raffaele, Milan, Italy.
出版信息
BJU Int. 2007 Dec;100(6):1249-53. doi: 10.1111/j.1464-410X.2007.07147.x. Epub 2007 Sep 10.
OBJECTIVE
To test the association between autologous blood transfusion (ABT) and biochemical recurrence (BCR) after radical prostatectomy (RP) in a large group of contemporary patients.
PATIENTS AND METHODS
We analysed 1291 patients treated with RP; Kaplan-Meier analysis was used to graphically explore the association between ABT and BCR. Cox regression models addressed the association between ABT and BCR in univariate and multivariate analyses, after adjusting for preoperative prostate specific antigen level, pathological Gleason sum, extracapsular extension, seminal vesicle invasion and lymph node invasion.
RESULTS
Of all patients, 205 (15.4%) received perioperative ABT. The mean (median, range) follow-up was 43.2 (40.9, 0.3-145) months. BCR was recorded in 347 (26.9%) patients and the time to BCR was 25.2 (20.5, 0.3-107) months. Neither in univariate (P = 0.053) nor in multivariate (P = 0.2) Cox regression analyses was ABT a statistically significant or independent predictor of BCR.
CONCLUSION
Perioperative ABT does not predispose to a higher rate of BCR in patients after RP.
目的
在一大组当代患者中检测根治性前列腺切除术后自体输血（ABT）与生化复发（BCR）之间的关联。
患者与方法
我们分析了1291例行根治性前列腺切除术的患者；采用Kaplan-Meier分析以图表形式探究ABT与BCR之间的关联。在对术前前列腺特异性抗原水平、病理Gleason评分、包膜外侵犯、精囊侵犯和淋巴结侵犯进行校正后，Cox回归模型在单因素和多因素分析中探讨了ABT与BCR之间的关联。
结果
所有患者中，205例（15.4%）接受了围手术期ABT。平均（中位数，范围）随访时间为43.2（40.9，0.3 - 145）个月。347例（26.9%）患者出现BCR，BCR发生时间为25.2（20.5，0.3 - 107）个月。在单因素（P = 0.053）和多因素（P = 0.2）Cox回归分析中，ABT均不是BCR的统计学显著或独立预测因素。
结论
围手术期ABT不会使根治性前列腺切除术后患者的BCR发生率更高。
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