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用于估算脂肪族和芳香族甲基丙烯酸酯溶血活性的量子化学描述符。

Quantum-chemical descriptors for estimating hemolytic activity of aliphatic and aromatic methacrylates.

作者信息

Ishihara Mariko, Fujisawa Seiichiro

机构信息

Division of Chemistry, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama 350-0283, Japan.

出版信息

Chemosphere. 2008 Feb;70(10):1898-902. doi: 10.1016/j.chemosphere.2007.07.070. Epub 2007 Sep 11.

DOI:10.1016/j.chemosphere.2007.07.070
PMID:17850844
Abstract

Methacrylates such as methyl methacrylate (6), triethyleneglycol dimethacrylate (5) and bisphenol A glycidyldimethacrylate, bis-GMA, (8) are widely used as materials in dental resins perturbation of the phosphatidylcholine-cholesterol interaction. Such effects of aromatic methacrylates may be involved in their marked hemolytic action.

摘要

甲基丙烯酸酯类,如甲基丙烯酸甲酯(6)、三乙二醇二甲基丙烯酸酯(5)和双酚A缩水甘油醚二甲基丙烯酸酯(双-GMA,8),作为牙科树脂中破坏磷脂酰胆碱-胆固醇相互作用的材料被广泛使用。芳香族甲基丙烯酸酯的这种作用可能与其显著的溶血作用有关。

相似文献

1
Quantum-chemical descriptors for estimating hemolytic activity of aliphatic and aromatic methacrylates.用于估算脂肪族和芳香族甲基丙烯酸酯溶血活性的量子化学描述符。
Chemosphere. 2008 Feb;70(10):1898-902. doi: 10.1016/j.chemosphere.2007.07.070. Epub 2007 Sep 11.
2
Cytotoxic effects of acrylates and methacrylates: relationships of monomer structures and cytotoxicity.丙烯酸酯类和甲基丙烯酸酯类的细胞毒性作用:单体结构与细胞毒性的关系
J Biomed Mater Res. 1997 Dec 15;37(4):517-24. doi: 10.1002/(sici)1097-4636(19971215)37:4<517::aid-jbm10>3.0.co;2-5.
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Studies on hemolytic activity of bisphenol A diglycidyl methacrylate (BIS-GMA).双酚A二甲基丙烯酸缩水甘油酯(BIS-GMA)溶血活性的研究
J Dent Res. 1978 Jan;57(1):98-102. doi: 10.1177/00220345780570013101.
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Methacrylates in dental restorative materials.牙科修复材料中的甲基丙烯酸酯类。
Contact Dermatitis. 2004 Apr;50(4):233-7. doi: 10.1111/j.0105-1873.2004.00336.x.
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Acrylate and methacrylate esters: relationship of hemolytic activity and in vivo toxicity.
J Biomed Mater Res. 1983 Nov;17(6):945-57. doi: 10.1002/jbm.820170606.
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Changes in 1H-NMR chemical shifts of Bis-GMA and its related methacrylates induced by their interaction with phosphatidylcholine/cholesterol liposomes.双甲基丙烯酸缩水甘油酯(Bis-GMA)及其相关甲基丙烯酸酯与磷脂酰胆碱/胆固醇脂质体相互作用引起的¹H-NMR化学位移变化。
Dent Mater J. 1991 Dec;10(2):121-7. doi: 10.4012/dmj.10.121.
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A semi-empirical computational model for the inhibition of porcine cholesterol esterase.一种用于抑制猪胆固醇酯酶的半经验计算模型。
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What every dentist should know about bisphenol A.每位牙医都应该了解的关于双酚A的知识。
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Effects of photoinitiators for the visible-light resin system on hemolysis of dog erythrocytes and lipid peroxidation of their components.可见光树脂体系光引发剂对犬红细胞溶血及其成分脂质过氧化的影响。
J Dent Res. 1986 Sep;65(9):1186-90. doi: 10.1177/00220345860650091401.
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Release phenomena and toxicity in polymer-based dental restorative materials.聚合物基牙科修复材料中的释放现象与毒性
Acta Biomed. 2007 Dec;78(3):190-7.

引用本文的文献

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Cytotoxicity and Pro-/Anti-inflammatory Properties of Cinnamates, Acrylates and Methacrylates Against RAW264.7 Cells.肉桂酸盐、丙烯酸酯和甲基丙烯酸酯对RAW264.7细胞的细胞毒性及促炎/抗炎特性
In Vivo. 2018 Nov-Dec;32(6):1309-1322. doi: 10.21873/invivo.11381.
2
Relationships between base-catalyzed hydrolysis rates or glutathione reactivity for acrylates and methacrylates and their NMR spectra or heat of formation.丙烯酸酯和甲基丙烯酸酯的碱催化水解速率或谷胱甘肽反应活性与其核磁共振光谱或生成热之间的关系。
Int J Mol Sci. 2012;13(5):5789-5800. doi: 10.3390/ijms13055789. Epub 2012 Mar 13.
3
Mechanisms of action of (meth)acrylates in hemolytic activity, in vivo toxicity and dipalmitoylphosphatidylcholine (DPPC) liposomes determined using NMR spectroscopy.
(甲基)丙烯酸酯在溶血活性、体内毒性和使用 NMR 光谱法测定的二棕榈酰磷脂酰胆碱(DPPC)脂质体中的作用机制。
Int J Mol Sci. 2012;13(1):758-773. doi: 10.3390/ijms13010758. Epub 2012 Jan 12.