Fujisawa S, Kadoma Y, Masuhara E
J Dent Res. 1986 Sep;65(9):1186-90. doi: 10.1177/00220345860650091401.
The visible-light (VL) polymerizing resin system with photoinitiators (photosensitizer and reducing agent) is widely used in modern dentistry. In this system, polymerization is initiated by photochemical reactions between the photosensitizers (aromatic or aliphatic ketones) and reducing agents (tertiary amines) during VL irradiation. In order to simulate the VL resin-induced toxicity in dental pulps, the present investigation was conducted to determine whether hemolysis of dog erythrocytes and lipid peroxidation of their components occur on exposure to a VL resin system containing aromatic (9-fluorenone, benzil) or aliphatic ketones (camphoroquinone) plus tertiary amine [2-(dimethylamino) ethyl methacrylate]. It was demonstrated that the hemolysis and lipid peroxidation with aromatic ketones were markedly higher than with those of aliphatic ketones, even when the latter were used at higher concentrations. It was clear that peroxidation-induced hemolysis occurred and, further, that surface-active complexes between photosensitizers and reducing agents, which are formed by irradiation, promote hemolytic activity due to their hydrophobic interactions. VL resin-induced responses to dental pulps are probably promoted due to the double effects of unpolymerized monomers and of both radicals and surface-active complexes formed during irradiation.
带有光引发剂（光敏剂和还原剂）的可见光（VL）聚合树脂体系在现代牙科中被广泛使用。在该体系中，在可见光照射期间，聚合反应由光敏剂（芳香族或脂肪族酮）和还原剂（叔胺）之间的光化学反应引发。为了模拟VL树脂对牙髓的毒性，本研究旨在确定暴露于含有芳香族（9-芴酮、联苯甲酰）或脂肪族酮（樟脑醌）加叔胺[甲基丙烯酸2-（二甲氨基）乙酯]的VL树脂体系时，犬红细胞是否会发生溶血及其成分是否会发生脂质过氧化。结果表明，即使脂肪族酮使用浓度更高，芳香族酮引起的溶血和脂质过氧化也明显高于脂肪族酮。很明显发生了过氧化诱导的溶血，而且，由照射形成的光敏剂和还原剂之间的表面活性复合物由于其疏水相互作用而促进了溶血活性。VL树脂对牙髓的反应可能是由于未聚合单体以及照射期间形成的自由基和表面活性复合物的双重作用而加剧的。
