Gonzalez-Rey Elena, Delgado Mario
Departamento de Bioquimica Medica y Biologia Molecular, Universidad de Sevilla, Sevilla 41009, Spain.
Mol Cell Endocrinol. 2008 May 14;286(1-2):135-40. doi: 10.1016/j.mce.2007.08.001. Epub 2007 Aug 7.
Identification of the factors that regulate the immune tolerance and control the appearance of exacerbated inflammatory conditions is crucial for the development of new therapies of autoimmune diseases. Some neuropeptides and hormones have emerged as endogenous agents that participate in the regulation of the processes that ensure self-tolerance. Among them, cortistatin, an endogenous cyclic neuropeptide relative of somatostatin, has recently shown therapeutic potential for a variety of immune disorders. Here we examine the latest research findings, which indicate that cortistatin participates in maintaining immune tolerance in two distinct ways: by regulating the balance between pro-inflammatory and anti-inflammatory factors, and by inducing the emergence of regulatory T cells with suppressive activity against autoreactive T cell effectors.
识别调节免疫耐受并控制炎症加剧情况出现的因素对于自身免疫性疾病新疗法的开发至关重要。一些神经肽和激素已成为参与确保自身耐受过程调节的内源性因子。其中，可体他汀，一种生长抑素的内源性环神经肽，最近已显示出对多种免疫疾病的治疗潜力。在此，我们审视了最新的研究发现，这些发现表明可体他汀通过两种不同方式参与维持免疫耐受：通过调节促炎和抗炎因子之间的平衡，以及通过诱导产生对自身反应性T细胞效应器具有抑制活性的调节性T细胞。
