Weyenberg Stephanie Van, Hesta Myriam, Buyse Johan, Papadopoulos Georgios A, Janssens Geert P J
Laboratory of Animal Nutrition, Ghent University, Heidestraat 19, 9820 Merelbeke, Belgium.
Vet J. 2008 Nov;178(2):233-7. doi: 10.1016/j.tvjl.2007.07.018. Epub 2007 Sep 11.
To determine whether plasma leptin concentrations and glucose tolerance are affected by changes in energy balance, nine healthy Shetland ponies were fed at 140% followed by 75% of their maintenance requirements for 13 days in each of the two periods. Bodyweight was recorded every three days. Blood samples were taken every two days and analysed for leptin and cortisol. An oral glucose tolerance test was performed on day 7 of each period. Serial blood samples were analysed for glucose and insulin. Although bodyweight was not affected, plasma leptin concentrations increased (P<0.001) initially during overfeeding, but returned to previous values after 7 days. During underfeeding, plasma leptin concentrations decreased (P<0.001). Underfeeding was associated with a higher AUC for plasma glucose (P=0.02) and plasma insulin (P=0.05) resulting in a decreased glucose tolerance (AUC glucose/AUC insulin; P=0.008), probably due to a plasma cortisol increase caused by the reduced feed intake. It is concluded that changes in energy balance, without altering bodyweight, can influence plasma leptin concentrations in ponies.
为了确定能量平衡的变化是否会影响血浆瘦素浓度和葡萄糖耐量，选取9匹健康的设得兰矮种马，在两个阶段中，每个阶段均先以维持需求量的140%投喂13天，然后以75%的维持需求量投喂13天。每三天记录一次体重。每两天采集一次血样，分析其中瘦素和皮质醇的含量。在每个阶段的第7天进行口服葡萄糖耐量试验。对采集的系列血样分析葡萄糖和胰岛素含量。尽管体重未受影响，但在过量投喂初期血浆瘦素浓度升高（P<0.001），但7天后恢复到先前水平。在投喂不足期间，血浆瘦素浓度降低（P<0.001）。投喂不足与血浆葡萄糖（P=0.02）和血浆胰岛素（P=0.05）的曲线下面积（AUC）升高有关，导致葡萄糖耐量降低（葡萄糖AUC/胰岛素AUC；P=0.008），这可能是由于采食量减少导致血浆皮质醇增加所致。得出的结论是，在不改变体重的情况下，能量平衡的变化会影响矮种马的血浆瘦素浓度。
