Van Weyenberg S, Buyse J, Janssens G P J
Ghent University, Merelbeke, Belgium.
J Anim Physiol Anim Nutr (Berl). 2009 Apr;93(2):203-8. doi: 10.1111/j.1439-0396.2008.00807.x.
In this study 0 or 4 g of l-carnitine was supplemented for 7 days in a cross-over design of six healthy ponies to modulate glucose metabolism and leptin production. At the end of each period, serial blood samples were taken to measure glucose and insulin response, leptin, triglyceride (TG), non-esterified fatty acids (NEFA) and creatine phosphokinase. l-carnitine supplementation was associated with a decrease in postprandial plasma glucose and insulin concentration, indicating an enhanced glucose tolerance. In contrast, postprandial plasma leptin concentration was increased when l-carnitine was supplemented. Yet, this increase in leptin concentration was not preceded by an increase in insulin concentration, suggesting that other factors apart from plasma insulin concentration could influence plasma leptin concentration. Although NEFA and TG were not significantly influenced by l-carnitine supplementation under these experimental conditions, further research must clarify whether net TG synthesis might be responsible for this increase in leptin.
在本研究中，采用交叉设计，给6匹健康小马补充0克或4克左旋肉碱，为期7天，以调节葡萄糖代谢和瘦素生成。在每个阶段结束时，采集系列血样以测量葡萄糖和胰岛素反应、瘦素、甘油三酯（TG）、非酯化脂肪酸（NEFA）和肌酸磷酸激酶。补充左旋肉碱与餐后血浆葡萄糖和胰岛素浓度降低有关，表明葡萄糖耐量增强。相比之下，补充左旋肉碱时餐后血浆瘦素浓度升高。然而，瘦素浓度的这种升高之前胰岛素浓度并未升高，这表明除血浆胰岛素浓度外的其他因素可能影响血浆瘦素浓度。尽管在这些实验条件下补充左旋肉碱对NEFA和TG没有显著影响，但进一步的研究必须阐明净TG合成是否可能是导致瘦素升高的原因。
