Forauer Andrew R, Kent Elizabeth, Cwikiel Wojciech, Esper Peggy, Redman Bruce
Division of Vascular/Interventional Radiology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA.
Acta Oncol. 2007;46(7):1012-8. doi: 10.1080/02841860701280725.
To examine whether transcatheter embolization of bone metastases is an effective palliative option for patients with renal cell carcinoma (RCCa). A retrospective review of 21 patients presenting for palliative embolization of painful RCCa skeletal metastases was performed. Details regarding anatomic sites, procedural details, and embolization materials were collected. The clinical response of the patient was assessed from clinic visits and analgesic use. Thirty separate embolization procedures were used to treat 39 metastatic lesions (18 pelvic, 8 lower extremity, 3 upper extremity, 5 rib/chest well, and 5 vertebral lesions). Five patients underwent more than one embolization. Polyvinyl alcohol was used in all 30 embolization procedures. Additional embolic materials were used in 16 of 30 procedures. A clinical response was achieved at 36 treated sites; the mean duration fo the response was 5.5 months. Selective embolization of bony renal cell carcinoma metastases can provide effective palliation in a patient population which has limited therapeutic options.
为了研究经导管骨转移瘤栓塞术对于肾细胞癌(RCCa)患者是否是一种有效的姑息治疗选择。对21例因疼痛性RCCa骨转移而行姑息性栓塞术的患者进行了回顾性研究。收集了有关解剖部位、手术细节和栓塞材料的详细信息。通过临床就诊和止痛药物使用情况评估患者的临床反应。采用30次单独的栓塞手术治疗39个转移病灶(18个盆腔病灶、8个下肢病灶、3个上肢病灶、5个肋骨/胸壁病灶和5个椎体病灶)。5例患者接受了不止一次栓塞术。所有30次栓塞手术均使用了聚乙烯醇。30次手术中有16次使用了其他栓塞材料。36个治疗部位取得了临床反应;反应的平均持续时间为5.5个月。对于治疗选择有限的患者群体,选择性栓塞骨转移性肾细胞癌可提供有效的姑息治疗。