Pinder Colin, Bhakta Bipin, Kodavali Krishna
The Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, UK.
Disabil Rehabil. 2008;30(5):381-6. doi: 10.1080/09638280701353442.
Severe bilateral leg spasticity can cause severe symptoms and reduced quality of life in affected individuals. It is often unresponsive to treatment. The objective of this study was to review the effectiveness of intrathecal phenol in the treatment of severe bilateral leg spasticity.
A retrospective case notes review of patients treated with intrathecal phenol by a rehabilitation service was performed. A simple rating scale based on comments in the case notes was used to identify changes in spasticity and treatment goals.
Forty patients were identified as having been treated with intrathecal phenol over a 10-year period. All patients had improvements in their spasticity, 34 of which were rated as substantial or excellent. All patients (in whom the effect was documented), except one, had short-term improvement in the goals for treatment, 31 having substantial or excellent improvement. The effect was long lasting in many of the patients. Seven patients required repeat injections with similar outcomes. Seven patients experienced temporary side-effects.
Intrathecal phenol is a useful alternative in treating selected patients with chronic severe bilateral leg spasticity that is unresponsive to other treatments.
严重的双侧腿部痉挛会给患者带来严重症状并降低生活质量。它通常对治疗无反应。本研究的目的是评估鞘内注射苯酚治疗严重双侧腿部痉挛的有效性。
对康复服务机构采用鞘内注射苯酚治疗的患者进行回顾性病例记录审查。基于病例记录中的评论使用简单的评分量表来确定痉挛的变化和治疗目标。
在10年期间确定有40例患者接受了鞘内注射苯酚治疗。所有患者的痉挛都有改善，其中34例被评为显著或优秀。除1例患者外，所有患者（记录了效果的）治疗目标都有短期改善，31例有显著或优秀的改善。许多患者的效果持久。7例患者需要重复注射，结果相似。7例患者出现了暂时的副作用。
鞘内注射苯酚是治疗某些对其他治疗无反应的慢性严重双侧腿部痉挛患者的一种有用的替代方法。
