Murayama S, Inoue K, Kawakami H, Bouldin T W, Suzuki K
Department of Pathology (Neuropathology), School of Medicine, University of North Carolina, Chapel Hill 27599-7525.
Acta Neuropathol. 1991;82(6):456-61. doi: 10.1007/BF00293379.
We examined the primary motor area (PMA, Brodmann area 4) from 23 cases of adult-onset sporadic amyotrophic lateral sclerosis (ALS) with immunocytochemistry using anti-glial fibrillary acidic protein antibody. There was astrocytosis in the middle of the pyramidal cell layer in all cases except for one that did not present any upper motor neuron signs clinically. The astrocytosis was characterized by multiple clusters of astrocytes, some of which showed a close association with macrophages. In about a half of the cases, these multiple clusters of astrocytes became confluent and presented as a laminar astrocytosis in the middle of the pyramidal cell layer. Our studies demonstrate a unique pattern of astrocytosis in the PMA in ALS. This pattern of astrocytosis may be useful not only for diagnostic purposes, but also for a better understanding of the pathological process involving the PMA in ALS.
我们使用抗胶质纤维酸性蛋白抗体，通过免疫细胞化学方法检查了23例成人起病的散发性肌萎缩侧索硬化症（ALS）患者的初级运动区（PMA，布罗德曼4区）。除1例临床上未出现任何上运动神经元体征的病例外，所有病例的锥体细胞层中部均存在星形细胞增生。星形细胞增生的特征是多个星形细胞簇，其中一些与巨噬细胞关系密切。在大约一半的病例中，这些多个星形细胞簇融合在一起，在锥体细胞层中部呈现为层状星形细胞增生。我们的研究证明了ALS患者PMA中星形细胞增生的独特模式。这种星形细胞增生模式不仅可能有助于诊断，还可能有助于更好地理解ALS中涉及PMA的病理过程。
