Murayama S, Bouldin T W, Suzuki K
Department of Pathology (Neuropathology), School of Medicine, University of North Carolina, Chapel Hill 27599-7525.
Acta Neuropathol. 1991;82(6):462-70. doi: 10.1007/BF00293380.
We have demonstrated onion bulb-like structures in human dorsal root ganglia (DRG). These onion bulbs morphologically consist of non-continuous layers of supporting-cell cytoplasms that encase thinly myelinated axons and are immunocytochemically recognized by anti-S-100 protein and anti-glial fibrillary acidic protein antibodies. These structures are present in normal controls and preferentially involve the initial complex of the large, light, neurofilament-rich neurons. The number of onion bulbs and their average number of lamellae reach a peak in the third decade and then decline. In three cases of amyotrophic lateral sclerosis (ALS), the onion bulbs involve non-myelinated axons as well as the thinly myelinated portion of the initial complex and are increased both in frequency and in average number of lamellae. Our studies suggest that these onion bulbs represent a normal biological process of DRG neurons that may be accentuated in ALS.
我们已经在人类背根神经节（DRG）中证实了葱球状结构。这些葱球在形态上由支持细胞细胞质的不连续层组成，这些层包裹着薄髓鞘轴突，并且通过抗S-100蛋白和抗胶质纤维酸性蛋白抗体进行免疫细胞化学识别。这些结构存在于正常对照中，并且优先累及大的、浅色的、富含神经丝的神经元的起始复合体。葱球的数量及其平均板层数在第三个十年达到峰值，然后下降。在三例肌萎缩侧索硬化症（ALS）中，葱球累及无髓鞘轴突以及起始复合体的薄髓鞘部分，并且在频率和平均板层数上均增加。我们的研究表明，这些葱球代表了DRG神经元的正常生物学过程，而这一过程在ALS中可能会加剧。
