Lamarche J, Luneau C, Lemieux B
Can J Neurol Sci. 1982 May;9(2):137-9. doi: 10.1017/s0317167100043833.
We report the preliminary study of a dorsal root ganglion obtained at biopsy during a surgical intervention in a patient with Friedreich's ataxia. There was an apparent decrease in the number of large myelinated fibers without necrosis, but with numerous axonal swellings consisting mainly of dense accumulated neurofilaments. Large amounts of lipofuscin were also found as well as some onion bulb formations suggesting a process of axonal atrophy.
我们报告了在对一名弗里德赖希共济失调患者进行手术干预时，通过活检获取的背根神经节的初步研究。大的有髓纤维数量明显减少，无坏死，但有大量主要由密集堆积的神经丝组成的轴突肿胀。还发现了大量脂褐素以及一些洋葱球样结构，提示存在轴突萎缩过程。
