胃排空：三种方法的比较
Gastric emptying: a comparison of three methods.
作者信息
Glerup Henning, Bluhme Henrik, Villadsen Gerda E, Rasmussen Karin, Ejskjaer Niels, Dahlerup Jens F
机构信息
Department of Internal Medicine, Regionhospital Silkeborg, Denmark.
出版信息
Scand J Gastroenterol. 2007 Oct;42(10):1182-6. doi: 10.1080/00365520701370922.
OBJECTIVE
A better understanding of the clinical relevance of delayed gastric emptying (e.g. in diabetes) requires a simple, easily accessible and inexpensive method for measuring it. Two "new" methods for measuring gastric emptying of liquids (the paracetamol absorption test and the 13C-acetate breath test) are compared with the gold standard (gastric emptying scintigraphy (GES)).
MATERIAL AND METHODS
The three techniques were used simultaneously in 10 healthy subjects. A gastric emptying time-retention curve was drawn for each technique and the results were compared at the 75%, 50% and 25% retention quartiles.
RESULTS
Agreement was found between the paracetamol absorption test and GES (p=0.95; Hotelling's T 2 test). Using the Wagner-Nelson one compartment correction produced a retention curve for the 13C-acetate breath test statistically significantly below GES (p<0.01).
CONCLUSION
In healthy subjects, the paracetamol absorption test produced results comparable to those of liquid GES, but not to the results of the 13C-acetate breath test.
目的
要更好地理解胃排空延迟（如在糖尿病中）的临床相关性，需要一种简单、易于获取且成本低廉的测量方法。将两种测量液体胃排空的“新”方法（对乙酰氨基酚吸收试验和13C - 乙酸呼气试验）与金标准（胃排空闪烁扫描术（GES））进行比较。
材料与方法
在10名健康受试者中同时使用这三种技术。为每种技术绘制胃排空时间 - 潴留曲线，并在潴留四分位数的75%、50%和25%处比较结果。
结果
对乙酰氨基酚吸收试验与GES之间存在一致性（p = 0.95；霍特林T²检验）。使用瓦格纳 - 尼尔森单室校正法得出的13C - 乙酸呼气试验的潴留曲线在统计学上显著低于GES（p < 0.01）。
结论
在健康受试者中，对乙酰氨基酚吸收试验的结果与液体GES的结果相当，但与13C - 乙酸呼气试验的结果不同。
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