Sanaka M, Nakada K
Department of General Medicine and Emergency Care, Toho University School of Medicine, Tokyo, Japan.
Methods Find Exp Clin Pharmacol. 2008 Dec;30(10):753-6. doi: 10.1358/mf.2008.30.10.1316828.
The physiological and pharmacological aspects of gastric emptying in fertile or pregnant women have been studied. Scintigraphy is the reference method for measuring gastric emptying. However, it should be applied very cautiously to women of childbearing age because of the risk of substantial irratiation. In such a population, paracetamol absorption has been used safely as an index of gastric emptying, but its accuracy has been challenged. The Wagner-Nelson method is a traditional tool used to precisely evaluate drug absorption kinetics. To clarify whether the absorption kinetics of paracetamol assessed by the Wagner-Nelson method is as accurate as scintigraphy in evaluating gastric emptying in young women, gastric emptying of a 200-kcal liquid meal was measured simultaneously by scintigraphy and the paracetamol test in 10 healthy young female volunteers. Paracetamol absorption systemically overestimated the rate of gastric emptying measured by scintigraphy. By introducing a correction factor into the paracetamol test, the overestimation could be adjusted. The paracetamol test with Wagner-Nelson analysis can be a safe and accurate method for measuring gastric emptying in women of childbearing age.
已对育龄或怀孕女性胃排空的生理和药理学方面进行了研究。闪烁扫描法是测量胃排空的参考方法。然而，由于存在大量辐射风险，应非常谨慎地将其应用于育龄女性。在这类人群中，对乙酰氨基酚的吸收已被安全地用作胃排空的指标，但其准确性受到了质疑。瓦格纳-尼尔森法是一种用于精确评估药物吸收动力学的传统工具。为了阐明通过瓦格纳-尼尔森法评估的对乙酰氨基酚的吸收动力学在评估年轻女性胃排空方面是否与闪烁扫描法一样准确，在10名健康年轻女性志愿者中，通过闪烁扫描法和对乙酰氨基酚试验同时测量了200千卡液体餐的胃排空情况。对乙酰氨基酚的全身吸收高估了通过闪烁扫描法测得的胃排空速率。通过在对乙酰氨基酚试验中引入校正因子，可以调整这种高估。采用瓦格纳-尼尔森分析的对乙酰氨基酚试验可以是一种安全准确的测量育龄女性胃排空的方法。
