Athlin Simon, Vikerfors Tomas, Fredlund Hans, Olcén Per
Department of Infectious Diseases, University Hospital, Orebro, Sweden.
Scand J Infect Dis. 2007;39(10):911-3. doi: 10.1080/00365540701367827.
We report a case of laboratory-acquired meningococcal disease in a 31-y-old female research assistant. The clinical presentation of the case was atypical with polyserositis affecting knees, pleura and pericardium, without septicaemia or meningitis. The diagnosis was made by positive PCR for Neisseria meningitidis (genogroup C, genosubtype P1.7, 16, 35 and without mutations of the penA gene) in the patient's right knee. Serology confirmed the diagnosis after recovery. This case had an atypical clinical picture, exemplifies the use of non-culture methods for diagnosis and characterization, and reminds us about the importance of safe routines for the laboratory work.
我们报告了一例31岁女性研究助理实验室获得性脑膜炎球菌病病例。该病例临床表现不典型，有多浆膜炎累及膝盖、胸膜和心包，无败血症或脑膜炎。通过患者右膝中脑膜炎奈瑟菌（C群，基因亚型P1.7、16、35且penA基因无突变）的聚合酶链反应（PCR）阳性做出诊断。血清学检查在患者康复后证实了诊断。该病例具有非典型临床表现，例证了非培养方法在诊断和特征鉴定中的应用，并提醒我们实验室工作安全规程的重要性。
