Turgut Faruk, Bayrak Omer, Kanbay Mehmet, Ozkara Adem, Uz Ebru, Bavbek Nuket, Kargili Ayse, Akcay Ali
Department of Internal Medicine, Division of Nephrology, Fatih University, Ankara, Turkey.
Scand J Urol Nephrol. 2008;42(1):47-52. doi: 10.1080/00365590701520008. Epub 2007 Jul 31.
Nocturia, a common and bothersome symptom of benign prostatic hyperplasia (BPH), may cause sleep disturbances. Patients with nocturia may have difficulty returning to their normal sleep after repeated episodes of waking and voiding. Therefore, nocturia may have an impact on the circadian rhythm of blood pressure (BP). The association between nocturia and the circadian rhythm of BP was investigated in this study.
A total of 100 male patients who had been diagnosed with BPH and 53 healthy male subjects were included in the study. Nocturnal urinary frequency was assessed by means of a questionnaire and recorded in both groups. Ambulatory BP monitoring was performed in all patients over a 24-h period.
Patient characteristics and laboratory parameters were similar in both groups. Seventy-five patients (75%) in the BPH group and 20 subjects (37.7%) in the control group were non-dippers, i.e. they did not have a normal nocturnal fall in BP, and this difference was statistically significant (p=0.001). Eighty-nine patients in the BPH group and 13 in the control group had nocturia. Seventy-one patients (79.8%) with nocturia were non-dippers and the difference compared to the patients without nocturia in the BPH group was significant (p=0.003), whereas four patients with nocturia (30.8%) were non-dippers in the control group.
Our findings indicate that non-dipping was more prevalent in elderly men with BPH and nocturia. BPH and nocturia may be etiological factors in the pathogenesis of non-dipping, which is an indicator of early cardiovascular disease. Further studies must focus on this relationship and, especially, on whether treatment of nocturia and BPH helps to treat non-dipping or not.
夜尿症是良性前列腺增生（BPH）常见且令人困扰的症状，可能导致睡眠障碍。夜尿症患者在反复醒来排尿后可能难以恢复正常睡眠。因此，夜尿症可能会影响血压（BP）的昼夜节律。本研究调查了夜尿症与血压昼夜节律之间的关联。
本研究共纳入100例被诊断为BPH的男性患者和53名健康男性受试者。通过问卷调查评估两组的夜间排尿频率并进行记录。对所有患者进行24小时动态血压监测。
两组患者的特征和实验室参数相似。BPH组中有75例患者（75%）和对照组中有20名受试者（37.7%）为非勺型血压者，即他们夜间血压没有正常下降，且这种差异具有统计学意义（p=0.001）。BPH组中有89例患者和对照组中有13例患者有夜尿症。BPH组中71例（79.8%）有夜尿症的患者为非勺型血压者，与该组无夜尿症的患者相比差异显著（p=0.003），而对照组中有4例有夜尿症的患者（30.8%）为非勺型血压者。
我们的研究结果表明，非勺型血压在患有BPH和夜尿症的老年男性中更为普遍。BPH和夜尿症可能是非勺型血压发病机制中的病因因素，而非勺型血压是早期心血管疾病的一个指标。进一步的研究必须关注这种关系，特别是夜尿症和BPH的治疗是否有助于治疗非勺型血压。
