Adachi Kazunori, Lee Jye-Chang, Hu James W, Yao Dongyuan, Sessle Barry J
Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.
Somatosens Mot Res. 2007 Sep;24(3):97-109. doi: 10.1080/08990220701470451.
The aim of this study was to determine if lingual nerve trauma affects the features of face primary motor cortex (MI) defined by intracortical microstimulation (ICMS). The left lingual nerve was transected in adult male rats by an oral surgical procedure; sham rats (oral surgery but no nerve transection) as well as naive intact rats served as control groups. ICMS was applied at post-operative days 0, 7, 14, 21, and 28 to map the jaw and tongue motor representations in face MI by analyzing ICMS-evoked movements and electromyographic activity recorded in the genioglossus (GG) and anterior digastric (AD) muscles. There were no statistically significant effects of acute (day 0) nerve transection or sham procedure (p > 0.05). The surgery in the sham animals was associated with limited post-operative change; this was reflected in a significant (p < 0.05) increase in the number of GG sites in left MI at post-operative day 14 compared to day 0. However, nerve transection was associated with significant increases in the total number of AD and GG sites in left or right MI or specifically the number of GG sites in rats at post-operative days 21 or 28 compared to earlier time periods. There were also significant differences between nerve-transected and sham groups at post-operative days 7, 14, or 21. These findings suggest that lingual nerve transection is associated with significant time-dependent neuroplastic changes in the tongue motor representations in face MI.
本研究的目的是确定舌神经损伤是否会影响由皮质内微刺激（ICMS）定义的面部初级运动皮层（MI）的特征。成年雄性大鼠通过口腔外科手术切断左侧舌神经；假手术组大鼠（进行口腔手术但不切断神经）以及未处理的完整大鼠作为对照组。在术后第0、7、14、21和28天应用ICMS，通过分析ICMS诱发的运动以及在颏舌肌（GG）和二腹肌前腹（AD）肌肉中记录的肌电图活动，来绘制面部MI中下颌和舌的运动代表区。急性（第0天）神经切断或假手术均无统计学显著影响（p>0.05）。假手术动物的手术与术后有限的变化相关；这体现在与第0天相比，术后第14天左侧MI中GG位点数量显著增加（p<0.05）。然而，与早期时间段相比，在术后第21天或28天，神经切断与左侧或右侧MI中AD和GG位点总数的显著增加相关，特别是大鼠中GG位点的数量。在术后第7、14或21天，神经切断组和假手术组之间也存在显著差异。这些发现表明，舌神经切断与面部MI中舌运动代表区显著的时间依赖性神经可塑性变化相关。
