Gursel Turkiz, Kocak Ulker, Kaya Zuhre, Bukulmez Aysegul, Atalay Yildiz
Pediatric Hematology Unit, Department of Pediatrics, Gazi University School of Medicine, Ankara, Turkey.
J Matern Fetal Neonatal Med. 2007 Nov;20(11):797-801. doi: 10.1080/14767050701500299.
Newborns are susceptible to thrombosis secondary to the immature hemostatic system and maternal and fetal complications. The contribution of activated protein C resistance (APCR) to thrombosis tendency has not yet been established. This study was conducted to investigate the effects of maternal and fetal complications on APCR levels.
APCR levels were determined in cord blood from healthy term infants and compared with those in healthy preterm and complicated neonates as well as that in adult venous blood.
The mean value of APCR in cord blood from healthy term infants (166 +/- 40 s) was not significantly different from that in adult venous blood (173 +/- 40 s). No significant differences in the mean cord blood APCR values were observed between healthy term and preterm infants, infants with vaginal and cesarean delivery, infants from preeclamptic and non-eclamptic mothers, and infants with or without perinatal asphyxia. The activity levels of protein C, protein S, and antithrombin III were not significantly different between these groups except for lower levels in preterm babies.
The level of APCR in cord blood is comparable to that in adults and not influenced by maternal and fetal complications. It appears that APCR does not contribute to the thrombotic tendency in newborns.
由于止血系统不成熟以及母婴并发症，新生儿易发生血栓形成。活化蛋白C抵抗（APCR）对血栓形成倾向的影响尚未明确。本研究旨在调查母婴并发症对APCR水平的影响。
测定健康足月儿脐血中的APCR水平，并与健康早产儿、复杂情况新生儿以及成人静脉血中的APCR水平进行比较。
健康足月儿脐血中APCR的平均值（166±40秒）与成人静脉血中的平均值（173±40秒）无显著差异。在健康足月儿与早产儿、经阴道分娩与剖宫产分娩的婴儿、子痫前期与非子痫前期母亲的婴儿以及有或无围产期窒息的婴儿之间，脐血APCR平均值无显著差异。除早产儿水平较低外，这些组之间蛋白C、蛋白S和抗凝血酶III的活性水平无显著差异。
脐血中APCR水平与成人相当，且不受母婴并发症影响。似乎APCR对新生儿的血栓形成倾向无影响。
