Iranpour Ramin, Zandian Ali, Mohammadizadeh Majid, Mohammadzadeh Ashraf, Balali-Mood Mahdi, Hajiheydari Mehnosh
Department of Pediatrics, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Zhongguo Dang Dai Er Ke Za Zhi. 2009 Jul;11(7):513-6.
Selenium is an essential trace element and has a main role in cellular antioxidant defense system. In very preterm babies, low selenium is associated with an increased risk of complications such as chronic neonatal lung disease and retinopathy of prematurity. This study was designed to determine and compare maternal and umbilical cord blood selenium levels in term and preterm infants.
From February 2008 to April 2008, 30 term (gestational age>37 weeks) and 30 preterm infants (gestational age<34 weeks) and their mothers were enrolled. Selenium concentrations in umbilical cord and maternal venous blood were measured by atomic absorption spectrometry.
The mean selenium concentration in term infants was higher than in preterm infants (124.80+/-13.72 microg/L vs 100.30+/-11.72 microg/L, P=0.0001). The mean selenium concentration in mothers of term and preterm infants was not significantly different (117.03+/-17.15 microg/L vs 110.56+/-17.49 microg/L, P=0.15). Cord selenium concentrations were strongly correlated with gestational age and birth weight (r=0.66, p<0.0001 and r=0.59, p<0.0001, respectively) when the data of all infants were analyzed together. None of the 60 women had a serum selenium level below the laboratory lower limit of normal (70.0 microg/L). Maternal selenium levels were correlated with cord selenium levels in their infants (r=0.40, p<0.001) when data of all newborn infants and mothers were considered together.
Mothers have a relatively good selenium status and serum selenium is not a significant predictor of preterm delivery in Isfahan. The cord selenium concentration in term infants is significantly higher than in preterm infants, but the cord selenium concentrations in both groups are in a suggested normal range.
硒是一种必需的微量元素，在细胞抗氧化防御系统中起主要作用。在极早产儿中，低硒与慢性新生儿肺病和早产儿视网膜病变等并发症风险增加有关。本研究旨在测定并比较足月儿和早产儿的母亲及脐带血中的硒水平。
2008年2月至2008年4月，纳入30名足月儿（胎龄>37周）、30名早产儿（胎龄<34周）及其母亲。采用原子吸收光谱法测定脐带血和母亲静脉血中的硒浓度。
足月儿的平均硒浓度高于早产儿（124.80±13.72μg/L对100.30±11.72μg/L，P=0.0001）。足月儿和早产儿母亲的平均硒浓度无显著差异（117.03±17.15μg/L对110.56±17.49μg/L，P=0.15）。将所有婴儿的数据一起分析时，脐带硒浓度与胎龄和出生体重密切相关（分别为r=0.66，p<0.0001和r=0.59，p<0.0001）。60名女性中无一例血清硒水平低于实验室正常下限（70.0μg/L）。将所有新生儿及其母亲的数据综合考虑时，母亲的硒水平与其婴儿的脐带硒水平相关（r=0.40，p<0.001）。
在伊斯法罕，母亲的硒状态相对良好，血清硒不是早产的重要预测指标。足月儿的脐带硒浓度显著高于早产儿，但两组的脐带硒浓度均在建议的正常范围内。
